Identification of asthma patients who are candidates for effecti

Details Identification of asthma patients who are candidates for effecti Identification of asthma patients who are candidates for effecti

1997-04-25

2000-07-18

McKelvey, Terry

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, C12Q 168, G01N 3353

Patent

active

060905476

ABSTRACT:
The present invention provides identification of sequence polymorphisms in the 5-lipoxygenase gene that are present in general and asthmatic populations. The invention provides methods associated with correlating such polymorphisms with asthmatic phenotype and responsiveness to therapy. In particular, the invention demonstrates that individuals with reduced 5-lipoxygenase expression (or activity) are less responsive to treatment with 5-lipoxygenase inhibiters.

REFERENCES:
Hoshiko, et al., "Characterization of the Human 5-Lipoxygenase Gene Promoter", Proc. Natl. Acad. Sci. USA, vol. 87, pp. 9073-9077 (Dec., 1990).
Israel, et al., "The Effect of Inhibition of 5-Lipoxygenase by Zileuton in Mild-to-Moderate Asthma" Annals of Internal Medicine, vol. 119, No. 11, pp. 1059-1066 (Dec. 1, 1993).
Israel, et al., "Effect of Treatment with Zileuton, 1 5-Lipoxygenase Inhibitor, in Patients with Asthma" JAMA, vol. 275, No. 12, pp. 931-936 (Mar. 27, 1996).
Khachigian, et al., "Egr-1-Induced Endothelial Gene Expresion: A Common Theme in Vascular Injury", Science, vol. 271, pp. 1427-1431 (Mar. 8, 1996).
Laursen, et al., "Selective 5-lipoxygenase Inhibition in ulcerative Colitis", The Lancet, vol. 335, pp. 683-685 (1990).
Lewis, et al., "The Biologically Active Leukotrienes", The American Society for Clinical Investigation, Inc., vol. 73, pp. 889-897 (Apr. 1984).
Margolskee, "Clinical Experience with MK-571: A Potent and Specific LTD.sub.4 Receptor Antagonist", Annals New York Academy of Sciences, vol. 629, pp. 148-156, 1991.
Persson, "Positive End-Expiratory Pressure Ventilation Elicits Increases in Endogenously Formed Nitric Oxide as Detected in Air Exhauled by Rabbits", Anesthesiology, vol. 82, No. 4, pp. 969-974 (Apr. 1995).
Samuelsson, "Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation" Science, vol. 220, pp. 568-575 (May 6, 1983).
Samuelsson, et al., "Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects", Science, vol. 237, pp. 1171-1176 (Sep. 4, 1987).
Weinblatt, et al., "Zileuton, A 5-Lipoxygenase Inhibitor in Rheumatoid Arthritis", The Journal of Rheumatology, vol. 19, No. 10, pp. 1537-1541 (1992).

Affiliated with

Also associated with

Rating

Identification of asthma patients who are candidates for effecti does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Identification of asthma patients who are candidates for effecti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of asthma patients who are candidates for effecti will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2034937