Identification of allele specific nucleic acid sequences by hybr

Details Identification of allele specific nucleic acid sequences by hybr Identification of allele specific nucleic acid sequences by hybr

1994-04-20

1997-07-29

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 435803, 435820, 436501, 536 221, 536 253, 549200, 549218, 549275, 935 77, 935 78, C12Q 168, C07H 2100

Patent

active

056520964

ABSTRACT:
Hybridization method for discriminating between complementarity and partial complementarity of DNA base sequences. Kinetic covalent entrapment of PCR-amplified target DNA is achieved through the use of crosslinkable probes. A crosslinking site is introduced into the target DNA via the PCR amplification process. Problems with renaturation of target DNA in the PCR process and in the hybridization reaction are minimized.

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