Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-04-15
2009-11-24
Clow, Lori A (Department: 1631)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C424S093100, C702S019000
Reexamination Certificate
active
07622271
ABSTRACT:
High throughput methods for screening genetic variants that are phenotypically distinguishable are provided. Methods for identifying “long-lived” genetic variants among a set of variants are also provided. Methods for identifying pharmaceutical compounds that can promote longevity in various subjects, including mammals, and that can delay the onset of various diseases associated with aging are also provided. Various vectors and host cells containing identified genes/gene products are useful for screening longevity-promoting compounds that can interact with life-span-regulating genes/gene products. Pharmaceutical compositions that can promote longevity are also provided.
REFERENCES:
Chen et al. (2003) Experimental Gerontology. vol. 38, pp. 1051-1063.
Fabrizio et al. (2004) FEBS Letters. vol. 557, pp. 136-142.
Itahana et al. (2003) Molecular and Cellular Biology. vol. 23, No. 1, pp. 389-401.
Kapahi et al. (2004) Current Biology. vol. 14, pp. 885-890.
Lin et al. (2000) Science. vol. 289, pp. 2126-2128.
Vellai et al. (2003) Nature. vol. 426, pp. 620-621.
Chen et al. Experimental Gerontology (2003) vol. 38, pp. 1051-1063.
Abraham, R. T. et al., “Immunopharmacology of Rapamycin,”Annu. Rev. Immuno.14, 483, 1996.
Beretta, L. et al., “Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation,”EMBO J.15(3), 658-664, 1996.
Brown, E. J. et al., “A mammalian protein targeted by G1-arresting rapamycin-receptor complex,”Nature369, 756-758, Jun. 30, 1994.
Dumont, F. J. et al., “Distinct Mechanisms of Supression of Murine T Cell Activation by the Related Macrolides FK-506 and Rapamycin,”J. Immunol144, 251-258, 1990.
Feldmann, H. et al., “Complete DNA sequence of yeast chromosome II,”EMBO J.13, 5795-5809, 1994.
Goffeau et al., “Life with 6000 Genes,”Science274, 546-547, 1996.
Huang, M-E. et al., “Analysis of a 62 kb DNA Sequence of Chromosome X Reveals 36 Open Reading Frames and a Gene Cluster with a Counterpart on Chromosome XI,”Yeast12, 869-875, 1996.
Jefferies, H. B. J. et al., “Rapamycin suppresses 5' TOP mRNA translation through inhibition of p70s6k,”EMBO J.16(12), 3693-3704, 1997.
Johnston, M. et al., “The nucleotide sequence ofSaccharomyces cerevisiaechromosome XII,”Nature387(6632), 87-90, 1997.
Kunz, J. et al., “Target of Rapamycin in Yeast, TOR2, Is an Essential Phosphatidylinositol Kinase Homolog Required for G1Progression,”Cell73, 585-596, 1993.
Philippsen, P. et al., “The nucleotide sequence ofSaccharomycesXIV and its evolutionary implications,”Nature387(6632), 93-98, 1997.
Raught, B. et al., “The target of rapamycin (TOR) proteins,”Proc. Natl. Acad. Sci U.S.A..98(13), 7037-7044, 2001.
Kaeberlein Matthew R.
Kennedy Brian K.
Clow Lori A
Fenwick & West LLP
University of Washington
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