Identification of activated receptors and ion channels

Details Identification of activated receptors and ion channels Identification of activated receptors and ion channels

2001-08-30

2008-12-09

Landsman, Robert (Department: 1646)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S006120, C435S007930, C435S440000, C435S325000, C435S069100

Reexamination Certificate

active

07462457

ABSTRACT:
The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels.

REFERENCES:
patent: 5683884 (1997-11-01), Moore et al.
patent: 5891646 (1999-04-01), Barak et al.
patent: 5981833 (1999-11-01), Wise et al.
patent: 6051386 (2000-04-01), Lerner et al.
Herrick-Davis et. al. J. Neurochem. 69: 1138-1144, 1997.
Parnot et al., Proc. Natl. Acad. Sci. 97: 7615-7620, 2000.
Han, M. et al. Constitutive Activation of Opsin by Mutation of Methionine 257 on Transmembrane Helix 6. Biochemistry 37, 8253-8261 (1998).
Lu, D. et al. A Ligand-Mimetic Model for Constitutive Activation of the Melanocortin-1 Receptor. Mol. Endocrinol. 12, 592-604 (1998).
McWhinney, C. et al. Constitutively Active Mutants of the alpha1a- and the alpha 1b-Adrenergic Receptor Subtypes Reveal Coupling to Different Signaling Pathways and Physiological Responses in Rat Cardiac Myocytes. J. Biol. Chem. 275, 2087-2097 (Jan. 21, 2000).
Pauwels, P.J. and Wurch, T. Review: Amino Acid Domains Involved in Constitutive Activation of G-Protein-Coupled Receptors. Mol. Neurobiol. 17, 109-135 (1998).
Spalding, T.A. et al. Constitutive Activation of the m5 Muscarinic Receptor by a Series of Mutations at the Extracellular End of Transmembrane 6. Biochemistry 36, 10109-10116 (1997).
Sommers, C.M., et al., “A Limited Spectrum of Mutations Causes Constitutive Activation of Yeast Alpha-Factor Receptor,” Biochemistry 39:6898-6909 (2000).

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