Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-03-21
2009-11-24
Ulm, John D (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C436S501000
Reexamination Certificate
active
07622266
ABSTRACT:
A method for identifying a synthetic ligand for retinoic acid receptor β comprises providing a sample, including a synthetic compound, exposing the sample to cultured cells, wherein the cultured cells comprise RARβ, determining if transcriptional expression of a gene encoding RARβ is upregulated compared to transcriptional expression of a control gene, and choosing a sample that upregulates the expression of RARβ as being a synthetic ligand for RARβ.
REFERENCES:
patent: 4859609 (1989-08-01), Dull et al.
patent: 4981784 (1991-01-01), Evans et al.
patent: A 0244221 (1987-11-01), None
patent: WO 88/03168 (1988-05-01), None
Maniatis, “Molecular Cloning—A Laboratory Manual”, pp. 199-209, Cold Spring Harbor Laboratory (1982).
Cato et al., “The Hormone Regulatory Element of Mouse Mammary Tumour Virus Mediates Progesterone Induction”, The EMBO Journal, vol. 5, No. 9, pp. 2237-2240 (1986).
Dejean et al., “Hepatitis B Virus DNA Intergration in a Sequence Homologous to v-erb-A and Steroid Receptor Genes in a Hepatocellular Carcinoma”, Nature, vol. 322, pp. 70-72 (1986).
Klein-Hitpass et al., “An Estrogen-Response Element Derived from the 5′ Flanking Region of the Xenopus Vitellogenin A2 Gene Functions in Transfected Human Cells”, Cell, vol. 46, pp. 1053-1061 (1986).
de The et al., “A Novel Steroid Thyroid Hormone Receptor Related Gene Inappropriately Expressed in Human Hepatocellular Carcinoma”, Nature, vol. 330, pp. 667-670 (1987).
Green and Chambon, “Oestradiol Induction of a Glucocorticoid-Responsive Gene by a Chimaeric Receptor”, Nature, vol. 325, pp. 75-78 (Jan. 1987).
Hollenberg et al., “Colocalization of DNA-Binding and Transcriptional Activation Functions in the Human Glucocorticoid Receptor”, Cell, vol. 49, pp. 39-46 (1987).
Kumar et al., “Functional Domains of the Human Estrogen Receptor”, Cell, vol. 51, pp. 941-951 (1987).
Miesfeld et al., “Glucocorticoid Receptor Mutants that Define a Small Region Sufficient for Enhancer Activation”, Science, vol. 230, pp. 423-437 (1987).
Petkovich et al., “A Human Retinoic Acid Receptor Which Belongs to the Family of Nucleic Acid Receptors”, Nature, vol. 330, pp. 444-450 (1987).
Benbrook et al., “A New Retinoic Acid Receptor Identified from a Hepatocellular Carcinoma”, Nature, vol. 333, p. 669-672 (1988).
Brand et al., “Identification of a Second Human Retinoic Acid Receptor”, Nature, vol. 332, pp. 850-853 (1988).
Evans, “The Steroid and Thyroid Hormone Receptor Superfamily”, Science, vol. 240, pp. 889-895 (1988).
Hauptmann et al., “A novel class of human type I interferons”, Nucleic Acids Research, vol. 13, pp. 4739-4749 (1985).
Green et al., “Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A”, Nature, vol. 320, pp. 134-139 (1986).
Weinberger et al., “Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product”, Nature, vol. 318, pp. 670-672 (1985).
Blaudin de The Hugues
Dejean Anne
Marchio Agnes
Tiollais Pierre
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Institut Pasteur
Ulm John D
LandOfFree
Identification of a synthetic ligand for retinoic acid... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Identification of a synthetic ligand for retinoic acid..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of a synthetic ligand for retinoic acid... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4111658