Identification of a new cytotoxic activity from the ink of...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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C530S350000, C514S002600, C424S185100

Reexamination Certificate

active

07074889

ABSTRACT:
The present invention relates to novel proteins having cytotoxic activity derived from the sea hareAplysia.

REFERENCES:
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patent: 6171818 (2001-01-01), Petzelt
patent: 2004/0029129 (2004-02-01), Wang et al.
patent: WO 97/16457 (1997-05-01), None
patent: WO 98/52971 (1998-11-01), None
Kamiya, H. et al. Toxicon. 1989; 27(12): 1269-1277 (Abstract).
Yamazaki M. et al., “Antitumor and Antimicrobial Glycoproteins from Sea Hares” Comparative Biochemistry and Physiology, 1993, vol. 105C, No. 2, pp. 141-146, XP002034987.
Yamazaki M. et al., “Purification of a Cytolytic Factor From Purple Fluid of a Sea-Hare Aplysia-Kurodai” FEBS Letters, 1986, vol. 198, No. 1, pp. 25-28, XP001002735.
Takamatsu N. et al., “Molecular Cloning of the Defense Factor in the Albumen Gland of the Sea Hare Aplysia Kurodai” FEBS Letters, Elsevier Science Publishers, 1995, vol. 377, No. 3, pp. 373-376, XP002035003.

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