Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2007-05-29
2007-05-29
Kerr, Kathleen M. (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C536S023200
Reexamination Certificate
active
10504034
ABSTRACT:
The invention relates to an isolated polynucleotide sequence comprising a nucleic acid sequence encoding the amino acid sequence of KshA protein or of KshB protein, encoded by nucleotides 499–1695 of SEQ ID NO: 1 or by nucleotides 387–1427 of SEQ ID NO:2, respectively, and functional homologues thereof. The polynucleotides of the invention can be used to construct genetically modified microorganisms blocked in 3-ketosteroid 9α-hydroxylase activity, which are useful in the microbial degradation of steroids to accumulate certain steroid products.
REFERENCES:
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Dijkhuizen Lubbert
Hessels Gerda
Van Der Geize Robert
Van Der Meijden Peter
Dubberley F. Aaron
Gebreyesus Kagnew
Kerr Kathleen M.
N.V. Organon
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