Identification and use of inhibitors of hair growth

Details Identification and use of inhibitors of hair growth Identification and use of inhibitors of hair growth

2002-03-06

2008-12-23

Ketter, James S (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S320100, C530S350000, C424S070100

Reexamination Certificate

active

07468246

ABSTRACT:
The invention relates to a method for the identification and/or production of an inhibitor of hair production. Moreover, the invention relates to a method for the inhibition of hair production. The invention also relates to a method for the production of a pharmaceutical composition. Furthermore, the invention relates to a pharmaceutical composition comprising an inhibitor of hair production identified or obtained according to one of the methods of the invention or a polynucleotide coding for the inhibitor, optionally in a pharmaceutically acceptable form of administration. The invention also relates to a pharmaceutical composition which comprises a polypeptide comprising the DNA-binding domain but not the transactivator domain of Whn, LEF-1 or Hoxc13, or a polynucleotide coding for said polypeptide, optionally in a pharmaceutically acceptable form of administration. Moreover, the invention relates to the use of a polypeptide comprising the DNA-binding domain but not the transactivator domain of Whn, LEF-1 or Hoxc13, or a polynucleotide coding for said polypeptide, of an inhibitor identified or obtained according to one of the methods of the invention or of a polynucleotide coding for such an inhibitor for the production of a pharmaceutical composition for the treatment of hair growth disorders. Not least, the invention relates to a kit for carrying out the methods of the invention.

REFERENCES:
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patent: WO 99/38965 (1999-08-01), None
patent: WO 01/74164 (2001-10-01), None
Charpentier et al., Journal of Cell Biology (2000) 149:503-519.
Dunn et al., J. Cell Sci. 91998) 111:3487-3496.
International Search Report mailed on Jan. 15, 2003, for PCT patent application No. PCT/EP02/02470 filed on Mar. 6, 2002, 6 pages.
Mizushima and Nagata, Nucleic Acids Research (1990) 18:5322.
Schlake et al., Proc. Natl. Acad. Sci. USA (1997) 94:3842-3847.
Schlake, Developmental Dynamics (2000) 217:368-376.
Schorp et al., Developmental Dynamics (2000) 218:537-543.

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