Identification and paternity determination by detecting presence

Details Identification and paternity determination by detecting presence Identification and paternity determination by detecting presence

1994-11-22

1997-07-08

Vogel, Nancy T.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 2431, C12Q 168, C07H 2104

Patent

active

056459904

ABSTRACT:
This invention relates to a process of identifying individuals or determining paternity by using Multiple Presence Polymorphic (MPP) probes. The invention also relates to Test Kits and Probes based on the process. The procedure uses multiple nucleic acid probes in separate hybridization tests, such as in different wells of a microtiter plate. The probes bind to nucleic acid sequences in some individuals, but not to others. The hybridization results convert to a unique pattern that can be used to identify an individual.

REFERENCES:
J.S. Beckmann, "Oligonucleotide Polymorphisms: A New Tool for Genomic Genetics", Bio/Technology 6 (1988) pp. 1061-1064.
M.F. Fey, "DNA fingerprints and hypervariable regions: genetic makers with numerous applications in medicine and biology", Schweizerische Medizinische Wochenschrift 23 (1989) pp. 815-825.
Wu et al., DNA, 8(2): 135-142 (1989).
Bogawan et al., Immunogenetics 32: 231-241 (1990).
Halmuth et al., Am. J. Hum. Genet., 47:515-523 1990.
Beckmann, Biotechnology, vol. 6, Sep. 1988, pp. 1061-1064.
Jeffreys et al, Nature, v. 332, Mar. 17, 1988, p. 278.
Gusella, Ann. Rev. Biochem, 1986, v. 55, p. 831.

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