Identification and engineering of antibodies with variant Fc...

Details Identification and engineering of antibodies with variant Fc... Identification and engineering of antibodies with variant Fc...

2011-08-23

2011-08-23

Dahle, Chun (Department: 1644)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S069100, C435S069600, C435S440000, C435S455000, C435S325000, C435S326000, C435S328000, C435S330000, C435S331000, C435S252300, C435S320100

Reexamination Certificate

active

08003774

ABSTRACT:
The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4752601 (1988-06-01), Hahn
patent: 5024835 (1991-06-01), Rao et al.
patent: 5225539 (1993-07-01), Winter
patent: 5348876 (1994-09-01), Michaelsen et al.
patent: 5576184 (1996-11-01), Better et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5624821 (1997-04-01), Winter et al.
patent: 5648260 (1997-07-01), Winter et al.
patent: 5693761 (1997-12-01), Queen et al.
patent: 5693762 (1997-12-01), Queen et al.
patent: 5698449 (1997-12-01), Baumann et al.
patent: 5711944 (1998-01-01), Gilbert et al.
patent: 5723584 (1998-03-01), Schatz
patent: 5736135 (1998-04-01), Goeddel et al.
patent: 5736137 (1998-04-01), Anderson et al.
patent: 5837243 (1998-11-01), Deo et al.
patent: 5874239 (1999-02-01), Schatz
patent: 5877396 (1999-03-01), Ravetch et al.
patent: 5888533 (1999-03-01), Dunn
patent: 5932433 (1999-08-01), Schatz
patent: 5945115 (1999-08-01), Dunn et al.
patent: 5985599 (1999-11-01), Mckenzie et al.
patent: 6019968 (2000-02-01), Platz et al.
patent: 6025485 (2000-02-01), Kamb et al.
patent: 6114147 (2000-09-01), Frenken et al.
patent: 6132764 (2000-10-01), Li et al.
patent: 6132992 (2000-10-01), Ledbetter et al.
patent: 6165745 (2000-12-01), Ward et al.
patent: 6180370 (2001-01-01), Queen et al.
patent: 6194551 (2001-02-01), Idusogie et al.
patent: 6218149 (2001-04-01), Morrison et al.
patent: 6242195 (2001-06-01), Idusogie et al.
patent: 6277375 (2001-08-01), Ward
patent: 6300065 (2001-10-01), Kieke et al.
patent: 6339069 (2002-01-01), Meers et al.
patent: 6420149 (2002-07-01), Fukuda et al.
patent: 6423538 (2002-07-01), Wittrup et al.
patent: 6455263 (2002-09-01), Payan
patent: 6472511 (2002-10-01), Leung et al.
patent: 6528624 (2003-03-01), Idusogie et al.
patent: 6538124 (2003-03-01), Idusogie et al.
patent: 6548640 (2003-04-01), Winter
patent: 6696550 (2004-02-01), Larosa et al.
patent: 6737056 (2004-05-01), Presta
patent: 6821505 (2004-11-01), Ward
patent: 6982321 (2006-01-01), Winter
patent: 7315786 (2008-01-01), Dahiyat et al.
patent: 7317091 (2008-01-01), Lazar et al.
patent: 7355008 (2008-04-01), Stavenhagen et al.
patent: 7425619 (2008-09-01), Koenig et al.
patent: 7425620 (2008-09-01), Koenig et al.
patent: 7632497 (2009-12-01), Stavenhagen
patent: 7655229 (2010-02-01), Chan et al.
patent: 7662925 (2010-02-01), Lazar et al.
patent: 7662926 (2010-02-01), Chan et al.
patent: 2001/0036459 (2001-11-01), Ravetch
patent: 2002/0004587 (2002-01-01), Miller et al.
patent: 2002/0028486 (2002-03-01), Morrison et al.
patent: 2003/0077282 (2003-04-01), Bigler et al.
patent: 2003/0115614 (2003-06-01), Kanda et al.
patent: 2003/0158389 (2003-08-01), Idusogie et al.
patent: 2003/0190319 (2003-10-01), Adolf et al.
patent: 2003/0207346 (2003-11-01), Arathoon et al.
patent: 2004/0002587 (2004-01-01), Watkins et al.
patent: 2004/0110226 (2004-06-01), Lazar et al.
patent: 2004/0132101 (2004-07-01), Lazar et al.
patent: 2004/0185045 (2004-09-01), Koenig et al.
patent: 2004/0191244 (2004-09-01), Presta
patent: 2004/0220388 (2004-11-01), Mertens et al.
patent: 2004/0235065 (2004-11-01), Hansen et al.
patent: 2004/0236078 (2004-11-01), Carter et al.
patent: 2005/0025764 (2005-02-01), Watkins et al.
patent: 2005/0037000 (2005-02-01), Stavenhagen et al.
patent: 2005/0054832 (2005-03-01), Lazar et al.
patent: 2005/0064514 (2005-03-01), Stavenhagen et al.
patent: 2005/0090648 (2005-04-01), Tsurushita et al.
patent: 2005/0215767 (2005-09-01), Koenig et al.
patent: 2005/0260213 (2005-11-01), Koenig et al.
patent: 2006/0013810 (2006-01-01), Johnson et al.
patent: 2006/0018899 (2006-01-01), Kao et al.
patent: 2006/0024298 (2006-02-01), Lazar et al.
patent: 2006/0073142 (2006-04-01), Chan et al.
patent: 2006/0134709 (2006-06-01), Stavenhagen et al.
patent: 2006/0177439 (2006-08-01), Koenig et al.
patent: 2007/0004909 (2007-01-01), Johnson et al.
patent: 2007/0036799 (2007-02-01), Stavenhagen et al.
patent: 2007/0253948 (2007-11-01), Chan et al.
patent: 2008/0044417 (2008-02-01), Johnson et al.
patent: 2008/0051563 (2008-02-01), Lazar et al.
patent: 2008/0131435 (2008-06-01), Stavenhagen et al.
patent: 2008/0138344 (2008-06-01), Stavenhagen et al.
patent: 2008/0286819 (2008-11-01), Ravetch et al.
patent: 2009/0053218 (2009-02-01), Koenig et al.
patent: 0 327 378 (1989-08-01), None
patent: 0 332 865 (1989-09-01), None
patent: 0 629 703 (1994-12-01), None
patent: 0 359 096 (1997-11-01), None
patent: 0 953 639 (1999-11-01), None
patent: 1 006 183 (2000-06-01), None
patent: 0 343 950 (2000-10-01), None
patent: 88/07089 (1988-09-01), None
patent: 89/07142 (1989-08-01), None
patent: 92/16562 (1992-10-01), None
patent: 93/22332 (1993-11-01), None
patent: 94/18330 (1994-08-01), None
patent: 94/29351 (1994-12-01), None
patent: 95/05468 (1995-02-01), None
patent: 97/28267 (1997-08-01), None
patent: 97/34631 (1997-09-01), None
patent: 97/44362 (1997-11-01), None
patent: 98/05787 (1998-02-01), None
patent: 98/23289 (1998-06-01), None
patent: 98/52975 (1998-11-01), None
patent: 99/19362 (1999-04-01), None
patent: 99/41285 (1999-08-01), None
patent: 99/43713 (1999-09-01), None
patent: 99/51642 (1999-10-01), None
patent: 99/58572 (1999-11-01), None
patent: 00/09560 (2000-02-01), None
patent: 00/42072 (2000-07-01), None
patent: 01/79299 (2001-10-01), None
patent: WO 02/02781 (2002-01-01), None
patent: 02/060919 (2002-08-01), None
patent: 02/086070 (2002-10-01), None
patent: 03/035835 (2003-05-01), None
patent: 03/066095 (2003-08-01), None
patent: 03/074679 (2003-09-01), None
patent: WO 03/074679 (2003-09-01), None
patent: WO 2004/016750 (2004-02-01), None
patent: WO 2004/029207 (2004-04-01), None
patent: WO 2004/063351 (2004-07-01), None
patent: WO 2004/065423 (2004-08-01), None
patent: WO 2004/074455 (2004-09-01), None
patent: WO 2004/099249 (2004-11-01), None
patent: WO 2005/018669 (2005-03-01), None
patent: WO 2005/070963 (2005-08-01), None
patent: WO 2005/110474 (2005-11-01), None
patent: WO 2005/115452 (2005-12-01), None
patent: WO 2006/020114 (2006-02-01), None
patent: WO 2006/028956 (2006-03-01), None
patent: WO 2006/066078 (2006-06-01), None
patent: WO 2006/088494 (2006-08-01), None
patent: WO 2006/113665 (2006-10-01), None
patent: WO 2007/021841 (2007-02-01), None
patent: 2007/024249 (2007-03-01), None
patent: WO 2007/024249 (2007-03-01), None
patent: WO 2007/106707 (2007-09-01), None
patent: WO 2008/002933 (2008-01-01), None
patent: WO 2008/009545 (2008-01-01), None
patent: WO 2008/019199 (2008-02-01), None
patent: WO 2009/083009 (2009-07-01), None
patent: WO 2009/151717 (2009-09-01), None
US 6,331,391, 12/2001, Wittrup et al. (withdrawn)
Rader et al. PNAS. 1998. 95:8910-8915.
Le Gall, F. et al. (Epub May 4, 2004) “Effect of Linker Sequences Between the Antibody Variable Domains on the Formation, Stability and Biological Activity of a Bispecific Tandem Diabody,” Protein Eng Des Sel. 17(4):357-366.
Polson, A.G. et al. (Epub Mar 20, 2007) “Antibody-Drug Conjugates Targeted to CD79 for the Treatment of Non-Hodgkin Lymphoma, ” Blood. 110(2):616-623.
PCT International Search Report and Written Opinion in counterpart International Application No. PCT/US 09/38201, dated Sep. 24, 2009

Affiliated with

Also associated with

Rating

Identification and engineering of antibodies with variant Fc... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Identification and engineering of antibodies with variant Fc..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification and engineering of antibodies with variant Fc... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2719354