Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-09-27
2005-09-27
Swartz, Rodney P (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C424S009100, C424S130100, C424S141100, C424S150100, C424S164100, C424S168100, C424S184100, C424S185100, C424S190100, C424S200100, C424S248100, C435S004000, C435S007200, C435S007320, C435S041000, C435S042000, C435S440000, C435S471000, C530S300000, C530S350000, C536S023100, C536S023700
Reexamination Certificate
active
06949345
ABSTRACT:
The present invention relates to peptide sequences enabling mycobacteria to adhere to host cells (e.g., epithelial cells). More particularly, the invention relates to a mycobacterial heparin-binding haemagglutinin type antigen fromM. bovisECG orM. tuberculosis. The invention also relates to a recombinant peptide sequence enabling mycobacteria to adhere to host cells. The polypeptides can be used to prepare vaccines against mycobacterial infections and for serological diagnosis of mycobacterial infections.
REFERENCES:
Menozzi et al, “A Heparin-Binding Hemagglutinin in mycobacteria”, Abstracts of the General Meeting of the American Society for Microbiology 95(0):193 (1995)—Abstract B-159 & 95thGeneral Meeting of the American Society for Microbiology, Washington, DC USA, May 21-25, 1995.
Brennan et al, “Identification of a Heparin-Binding Mycobacterial Hemagglutinin”, Journal of Cellular Biochemistry Supplement 0 (19B), p. 66 (1995)—Abstract B3-104 & Keystone Symposium on Molecular Mechanisms in Tuberculosis, Tamarron, Colorado, USA, Feb. 19-25, 1995.
Isaacs, “Borrelia burgdorferiBind to Epithelial Cell Proteoglycans”, Journal of Clinical Investigation 93:809-819 (1994).
Menozzi et al, “Heparin-Inhibitable Lectin Activity of the Filamentous Hemagglutinin Adhesin ofBordetella pertussis”, Infection and Immunity 62(3):769-778 (1994).
Hudson et al, “Comparison of the Fibronectin-binding Ability and Antitumor Efficacy of Various Mycobacteria”, Cancer Research 50:3843-3847 (1990).
Rouse et al, “Immunological Characterization of Recombinant Antigens Isolated from aMycobacterium aviumλgt11 Expression Library by Using Monoclonal Antibody Probes”, Infection and Immunity 59(8):2595-2600 (1991).
“Mycobacterium tuberculosiscosmid SCY20G9”, Banque De Donnees Embl, Identificateur MTCY20G9, Accession No. Z77162, Sep. 18, 1996.
Menozzi et al, “Identification of a Heparin-binding Hemagglutinin Present in Mycobacteria”, Journal of Experimental Medicine 184(3):993-1001 (1996).
Locht Camille
Menozzi Franco
Institut National de la Sante et de la Recherche Medicale
Institut Pasteur de Lille
Nixon & Vanderhye P.C.
Swartz Rodney P
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