Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-07-10
2007-07-10
Mertz, Prema (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S071100, C435S071200, C435S325000, C435S320100, C435S252300, C435S254110, C435S069700, C536S023500
Reexamination Certificate
active
09966955
ABSTRACT:
The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.
REFERENCES:
patent: 5116964 (1992-05-01), Capon et al.
patent: 6831151 (2004-12-01), Goitsuka
patent: 6943241 (2005-09-01), Isogai et al.
patent: 1033401 (2000-09-01), None
patent: 1 132 468 (2001-09-01), None
patent: 1308459 (2003-05-01), None
patent: 3146204 (1991-06-01), None
patent: 2005257347 (2005-09-01), None
patent: WO 01/21788 (2001-03-01), None
Mikayama et al. Proc. Natl. Acad. Sci. USA vol. 90, pp. 10056-10060.
Voet et al. Biochemistry John Wiley & Sons, Inc., pp. 126-128 and 228-234.
NCI Entrez Accession No. gi:8099157.
Goitsuka et al. Int. Immunol. 12(4):573-580 (2000).
Cao et al., J. Exp. Med. 190:1527-1534 (1999).
NCBI Entrez Accession No. gi:8099156.
Goitsuka, R., J. Of Clin. and Exp. Med., 192:1027-1031 (2000).
NCBI Entrez Accession No. AB032369 (gi:8099156), Goitsuka, et al., May 26, 2000.
NCBI Entrez Accession No. BAA96241 (gi:8099157), Goitsuka, et al., May 26, 2000.
Bolton, et al., “The Labelling of Proteins to High Specific Radioactivities by Conjugation to a125I-Containing Acylating Agent”, Biochem. J., vol. 133, pp. 529-539 (1973).
Lowenstei, et al., The SH2 and SH3 Domain-Containing Protein GRB2 Links Receptor Tyrosine Kinases to ras Signaling, Cell, vol. 70, pp. 431-442 (1992).
Lupher, et al., “The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction”, Immunology Today, vol. 20(8), pp. 375-382 (1999).
Polayes, et al., “New Baculovirus Expression Vectors for the Purification of Recombinant Proteins from Insect Cells”, Focus, vol. 18(1), pp. 10-13 (1996).
Zhang, et al., “LAT: The ZAP-70 Tyrosine Kinase Substrate that Links T Cell Receptor to Cellular Activation”, Cell, vol. 92, pp. 83-92 (1998).
Bateman, et al., “The Pfam Protein Families Database”, Nucl. Acids Res., vol. 28 (1), pp. 263-266 (2000).
Downward, Julian, “The GRB2/Sem-5 adaptor protein”, FEBS Letters, vol. 338, pp. 113-117 (1994).
Gout, et al., “The GTPase Dynamin Binds to and Is Activated by a Subset of SH3 Domains”, Cell, vol. 75, pp. 25-36 (1993).
Hochuli, et al., “New Metal Chelate Adsorbent Selective For Proteins And Peptides Containing Neighbouring Histidine Residues”, J. Chromatography, vol. 411, pp. 177-184 (1987).
Jackman, et al., Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 In T Cells, J. Biol. Chem., vol. 270(13),pp. 7029-7032 (1995).
Gilliland, et al., “Lymphocyte Lineage-restricted Tyrosine-phosphorylated Proteins That Bind PLCγ1 SH2 Domains”, J. Biol. Chem., vol. 267(19),pp. 13610-13616 (1992).
Luckow, et al., “Efficient Generation of Infectious Recombinant Baculoviruses by Site-Specific Transposon-Mediated Insertion of Foreign Genes into a Baculovirus Genome Propagated inEscherichia coli”, J. Virology, vol. 67(8), pp. 4566-4579 (1993).
Motto, et al., “In Vivo Association of Grb2 with pp116, a Substrate of the T Cell Antigen Receptor-activated Protein Tyrosine Kinase”, J. Biol. Chem., vol. 269(34), pp. 21608-21613 (1994).
Myung, et al., “Adapter proteins in lymphocyte artigen-receptor signaling”, Curr. Opin. Immunol., vol. 12, pp. 256-266 (2000).
O'Shea, et al., “Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation”, PNAS, vol. 89, pp. 10306-10310 (1992).
Reif, et al., “SH3 Domains of the Adapter Molecule Grb2 Complex with Two Proteins in T Cells: The Guanine Nucleotide Exchange Protein Sos and a 75-kDa Protein That Is a Substrate for T Cell Antigen Receptor-activated Tyrosine Kinases”, J. Biol. Chem., vol. 269(19), pp. 14081-14087 (1994).
Ren, et al., “Ab1 protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites”, Genes Develop., vol. 8, pp. 783-795 (1994).
Schrelber, S.L., “Immunophilin-Sensitive Protein Phosphatase Action in Cell Signaling Pathways”, Cell., vol. 70, pp. 365-368 (1992).
Tagle, et al., “Magnetic bead capture of expressed sequences encoded within large genomic segments”, Nature, vol. 361, pp. 751-753 (1993).
Tirona, et. al., “Polymorphisms in OATP-C”, J. Biol. Chem., vol. 276(38), pp. 35669-35675 (2001).
Tuosto, et al., “p95vavAssociates with Tyrosine-phosphorylated SLP-76 in Antigen-stimulated T Cells”, J. Exp. Med., vol. 184, pp. 1161-1166 (1996).
Heeke, et al., “Expression of Human Asparagine Synthetase InEscherichia coli”, J. Biol. Chem., vol. 264(10), pp. 5503-5509 (1989).
Watanabe, et. al., “Four Tyrosine Residues in Phospholipase C-γ2, Identified as Btk-dependent Phosphorylation Sites, Are Required for B Cell Antigen Receptor-coupled Calcium Signaling”, J. Biol. Chem., vol. 276(42), pp. 38595-38601 (2001).
Wu, et al., “Vav and SLP-76 Ineract and Functionally Cooperate in IL-2 Gene Activation”, Immunity, vol. 4, pp. 593-602 (1996).
Ye, et. al., “Binding of Vav to Grb2 through dimerization of Src homology 3 domains”, PNAS, vol. 91, pp. 12629-12633 (1994).
NCBI Entrez Accession No. AA166259 (gi:1744240), Marra M/Mouse Est Project, Dec. 19, 1996.
NCBI Entrez Accession No. AAW20767 (gi:56674094), Goitsuka, R., Dec. 15, 2004.
NCBI Entrez Accession No. ABA67702 (gi:77369954), Isogai, et al., Oct. 7, 2005.
NCBI Entrez Accession No. AF187819 (gi:6492365), Cao, et al., Dec. 1, 1999.
NCBI Entrez Accession No. BAC76765 (gi:30984140), Goitsuka, R., May 22, 2003.
NCBI Entrez Accession No. NP—443196 (gi:42734366), Goitsuka, et al., Nov. 29, 2005.
NCBI Entrez Accession No. XM—093920 (gi:42657102), NCBI Annotation Process, Feb. 19, 2004.
NCBI Entrez Accession No. NM—052964 (gi:42734365), Goitsuka, et al., Nov. 29, 2005.
NCBI Entrez Accession No. XP—093920 (gi:27477858), NCBI's Annotation Process, Feb. 19, 2004.
NCBI Entrez Accession No. XP—520687 (gi:55666927), NCBI's Annotation Process, Nov. 10, 2004.
NCBI Entrez Accession No. XM—093920 (gi:37540655), NCBI's Annotation Process, Oct. 17, 2003.
Swiss-Prot Accession No. Q9P2U9, Integrated Oct. 1, 2001, Annotations modified on May 30, 20064.
Chang Han
Kanner Steven B.
Perez-Villar Juan J.
Whitney Gena S.
Wu Yuli
Bristol--Myers Squibb Company
D'Amico Stephen C.
Klein Christopher A.
Mertz Prema
LandOfFree
Identification and cloning of a full-length human... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Identification and cloning of a full-length human..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification and cloning of a full-length human... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3787336