Identification and characterization of racemases, definition...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S069100, C435S232000, C435S320100, C435S325000, C536S023200, C536S024300

Reexamination Certificate

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11008570

ABSTRACT:
This invention provides identification and characterization of racemases and definition of protein signatures of these racemases. This invention also provides identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs. Antibodies specific for the peptides and to immune complexes of these antibodies with the peptides are also provided. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.

REFERENCES:
patent: 6459996 (2002-10-01), Somers et al.
patent: 6524589 (2003-02-01), Reichert et al.
patent: 6546074 (2003-04-01), Blundell et al.
patent: 6833447 (2004-12-01), Goldman et al.
patent: 2005/0250195 (2005-11-01), Minoprio et al.
patent: WO 01/40449 (2001-06-01), None
patent: WO-01/40449 (2001-06-01), None
patent: WO 0140449 (2001-06-01), None
patent: WO-2004/106506 (2004-12-01), None
Cardinale, G. J. et al., “Purification and Mechanism of Action of Proline Racemase,” Biochemistry, vol. 7, No. 11, pp. 3970-3978, (1968).
Chamond, N. et al., “Biochemical Characterization of Proline Racemases from the Human Protozoan ParasiteTrypanosoma Cruziand Definition of Protein Signatures,” The Journal of Biological Chemistry, vol. 278, No. 18, pp. 15484-15494, (May 2, 2003).
Delvecchio, V. G. et al., “The Genome Sequence of the Facultative Intracellular PathogenBrucella melitensis,” Abstract of Proc. Natl. Acad. Sci. U.S.A., vol. 99, No. 1, pp. 443-448, XP002290326, (2002).
Delvecchio, V. G, et al., “The Genome Sequence of the Facultative Intracellular PathogenBrucella melitensis,” Proc. Natl. Acad. Sci. U.S.A., vol. 99, No. 1, pp. 443-448, (Jan. 8, 2002).
Matsushita Elec. Ind. Co. Ltd., “Quantitative Qualitative Determination of Aminoacid by Converting One Optical Active Isomer to Another Using Amino acid Racemase and Oxidation,” Patent Abstract of JP. No. 55-081595, (Jun. 19, 1980).
Minoprio, P. et al., International Application No. WO 2004/072223 A2 (U.S. Appl. No. 10/545,149, filed Aug. 10, 2004).
Reina-San-Martín, B. et al., “A B-Cell Mitogen From a Pathogenic Trypanosome is a Eukaryotic Proline Racemase,” Nature Medicine, vol. 6, No. 8, pp. 890-897, (Aug. 2000).
Rudnick, G. et al., “Reaction Mechanism and Structure of the Active Site of Proline Racemase,” Biochemistry, vol. 14, No. 20, pp. 4515-4522, (1975).
Chamond et al.; “Immunotherapy ofTrypanosoma cruziInfections”; Current Drug Targets—Immune, Endocrine & Metabollic Disorders, vol. 2, No. 3, pp. 247-254, (2002).
Minoprio, P. et al., U.S. Appl. No. 10/558,371, filed Nov. 29, 2005. as a national stage application of PCT/IB04/002062, filed Feb. 11, 2004, and published as WO 2004/106506 A2.

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