Id-1 and Id-2 genes and products as markers of epithelial...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100

Reexamination Certificate

active

08030012

ABSTRACT:
A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

REFERENCES:
patent: 5650435 (1997-07-01), Madara et al.
patent: 6048850 (2000-04-01), Young et al.
patent: 7429457 (2008-09-01), Desprez et al.
Morrow MA et al, 1999 (Mol Immunol, 36(8): 491-503).
Accession No. S47524, by Deed et al, 1994, in MPSRCH search result, 2007, us-11-390-682.2.rpr, result 1, p. 1.
Maruyama et al, Sep. 1999, Amer J Pathol, 155 (3): 815-22.
Schmid S et al, 2001 (J comparative Neurology, 430(2): 160-71).
Conner et al, 1996 (Mol Brain Res, 42: 1-17.
Lin et al, Mar. 1, 2000, Cancer Res, 60: 1332-1340.
Hara et al, 1994, Accession No: A49727, 1994 in MPSRCH Search result, 2007, us-11-390-682.rpr.result 2, p. 1.
Van Dekken et al, 1997, Histochemistry and Cell Biology, 108 (4-5): p. 419-430.
Glinsky et al, 2004, J Clin Invest, 113: 913-923.
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
Oesterreich, S et al, 1996 (Clin Cancer Res, 2: 1199-1206.
Vandesompele J et al, 2003 (Oncogene, 22(3): 456-60).
Hu et al, Proceedings of the American Association for Cancer Research Annual Meeting (41): p. 315, Mar. 2000, abstract #2004.
Itahana et al, Proceedings of the American Association for Cancer Research Annual Meeting (41): p. 229 Mar. 2000, abstract #1459.
Takai et al., “Id1 Expression is Associated with Histological Grade and Invasive Behavior in Endometrial Carcinoma,” Cancer Letters, Elsiver Science Ltd., vol. 165, p. 185-193. (2001).
Schindl et al., “Overexpression of Id-1 Protein is a Marker for Unfavorable Pronosis in Early Stage Cervical Cancer,” Cancer Research, vol. 165, p. 5703-5706 (Aug. 1, 2001).
Schindl et al., “Level of Id-1 Protein Expression with Poor Differentiation Enhanced Malignant Potential, and More Agressive Clinical Behavior of Epithelial Ovarian Tumors,” Clinical Cancer Research, vol. 9, pp. 779-785, (Feb. 2003).
Schoppmann et al., “Overexpression of Id-1 is Associated with Poor Clinical Outcome in Node Negative Breast Cancer,” Int. J. Cancer, 2003 Wiley-Liss, Inc., vol. 104, p. 677-682, (2003).
Desprez et al., “Suppression of Mammary Epithelial Cell Differentiation by the Helix-Loop-Heliz Protein Id-1,” Molecular and Celluar Biology, vol. 15, No. 6, p. 3398-3404, (Jun. 1995).
Lin et al., “A Role for Id-1 in the Agressive Phenotype and Steroid Hormone Response of Human Breast Cancer Cells,” Cancer Research, vol. 60, p. 1332-1340, (Mar. 1, 2000).
Liu et al., “Systemic Gene Delivery Expands the Repertoire of Effective Antiangiogenic Agents,” The Journal of Biological Chemistry, vol. 274, No. 19, p. 13338-13344 (May 7, 1999).
Langlands et al., “Id Proteins are Dynamically Expressed in Normal Epidemis and Dysregulated in Squamous Cell Carcinoma,” Cancer Research, vol. 60, p. 5929-5933, (Nov. 1, 2000).
Benezra, “The Id Proteins: Targets for Inhibiting Tumor Cells and Their Blood Supply,” Biochimica et Biophysica Acta, vol. 1551 p. F39-F47, (2001).
Carter, et al., “Relation of Tumor Size, Lymph Node Status, and Survival in 24,740 Breast Cancer Cases,”Cancer63:181-187, 1989.
Coppe, et al., “Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression, ”Clin Cancer Res. Mar 15, 2004;10(6):2044-51.
Fong, et al., “Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis,”Proc Natl Acad Sci U S A. Nov. 11, 2003;100(23):13543-8. Epub Oct. 24, 2003.
Forootan, et al., Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancerHum Pathol. Sep. 2007;38(9):1321-9. Epub Jun. 28, 2007.
Hu, et al., “Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC,”Clin Cancer Res. Aug. 2001;7(8):2213-21.
Ouyang, “Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat,”Carcinogenesis. Jun. 2001;22(6):965-73.
Ouyang, et al., “Over expression of ID-1 in prostate cancer,”J Urol. Jun. 2002;167(6):2598-602.
Polsky, et al., “The transcriptional repressor of p16/Ink4a, Id1, is up-regulated in early melanomas,” Cancer Res. Aug. 15, 2001;61(16):6008-11.
Say, et al., “Invasive Carcinoma of the Breast: Prognostic Significance of Tumor Size and Involved Axillary Lymph Nodes,”Cancer34:468-471, 1974.
Straume, et al., “Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma,”British Journal of Cancer, (2005) 93, 933-938.
Yuen, et al., “Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma,”Br J Cancer. Nov. 19, 2007;97(10):1409-15. Epub Nov. 13, 2007.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Id-1 and Id-2 genes and products as markers of epithelial... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Id-1 and Id-2 genes and products as markers of epithelial..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Id-1 and Id-2 genes and products as markers of epithelial... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4280823

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.