Id-1 and Id-2 genes and products as markers of epithelial...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007230, C435S007900, C530S350000, C530S387100

Reexamination Certificate

active

09952534

ABSTRACT:
A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

REFERENCES:
patent: 6048850 (2000-04-01), Young et al.
Vandesompele J et al, 2003, Oncogene, 22(3): 456-60.
Maruyama, H et al, 1999, Amer J Pathol, 155(3) : 815-22.
Stewart, HJ et al, 1997, J Neurosci res,50(5): 684-701.
Hsu (in Tissue Culture Methods and Applications, Kruse and Patterson, Eds, 1973, Academic Press, NY, see abstract, p. 764).
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p4).
Dermer (Bio/Technology, 1994, 12:320).
Morrow MA et al, Mol Immunol, 1999, 36(8): 491-503.
Oesterreich, S et al, 1996, Clin Cancer Res, 2: 1199-1206.
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
Drexler et al (Leukemia and Lymphoma, 1993, 9:1-25).
Embleton et al. (Immunol Ser, 1984, 23:181-207).
Ausubel, FM, et al, eds, 1987, Current protocols in Molecular Biology, John Wiley & Sons, p. 6.3.5.
Schmid S et al, 2001, J comparative Neurology, 430(2): 160-71.
Conner et al, 1996, Mol Brain Res, 42: 1-17.
Bowie et al (Science, 1990, 257 : 1306-1310).
Burgess et al, (Journal of Cell Biology, 1990, 11: 2129-2138).
Lazar et al. Molecular and Cell Biology, 1988, 8: 1247-1252.
Tao. et al. The Journal of Immunology, 1989, 143(8): 2595-2601.
Gillies et al. Human Antibodies and Hybridomas, 1990, 1(1): 47-54).
Schmid S et al, 2001 (J comparative Neurology, 430(2): 160-71).
Conner et al, 1996 (Mol Brain Res, 42: 1-17).
Kenneth Langlands, et al., Id Proteins Are Dynamically Expressed in Normal Epidermis and Dysregulated in Squamous Cell Carcinoma,Cancer Research, 60:5929-5933 (Nov. 1, 2000).
Robert Benezra, The Id Proteins: Targets for Inhibiting Tumor Cells and Their Blood Supply,Biochimica et Biophysica Acta, 1551:F39-F47, (2001).
Claudia Qiao Lin, et al., A Role for Id-1 In the Aggressive Phenotype and Steroid Hormone Response of Human Breast Cancer Cells,Cancer Research, 60:1332-1340 (Mar. 1, 2000).
Yong Liu, et al., Systemic Gene Delivery Expands the Repertoire of Effective Antiangiogenic Agents, The Journal of Biological Chemistry, 274/19:13338-13344, (May 7, 1999).
Takai et al., “Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma,” Cancer Letters, Elsvier Science Ireland Ltd., vol. 165, p. 185-193, (2001).
Schindl et al., “Overexpression of Id-1 Protein is a Marker for Unfavorable Prognosis in Early-Stage Cervical Cancer,” Cancer Research, vol. 165, p. 5703-5706, (Aug. 1, 2001).
Schindl et al., “Level of Id-1 Protein Expression Correlates with Poor Differentiation, Enhanced Malignant Potential, and More Agressive Clinical Behavior of Epithelial Ovarian Tumors,” Clinical Cancer Research, vol. 9, p. 779-785, (Feb. 2003).
Schoppmann et al., “Overexpression of Id-1 is associated with Poor Clinical Outcome in Node Negative Breast Cancer,” Int. J. Cancer, 2003 Wiley-Liss, Inc., vol. 104, p. 677-682, (2003).

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