Icosahedral superstructure of VP2 of infectious bursitis...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S207100, C435S069100, C435S006120

Reexamination Certificate

active

07132105

ABSTRACT:
The IBDV VP2 icosahedral superstructures are made up of 12 empty VP2 dodecahedral capsids, lacking genetic material. They have a size of approximately 60–68 nm in diameter and contain 720 IBDV VP2 subunits. These VP2 icosahedral superstructures can be used for vaccinal and diagnostic purposes.

REFERENCES:
patent: 5605792 (1997-02-01), Jackwood et al.
Caston, Jose R. et al. “C terminus of infectious bursal deisease virus major capsid protein VP2 is involved in definition of the Tnumber for capsid assembly”. Nov. 2001. Journal of Virology. vol. 75(22). pp. 10815-10828.
Wang, Min-Ying et al. “Self assembly of the infectious bursal disease virus capsid protein, rVP2, expressed in insect cells and purification of immunogenic chimeric rVP2H particles by immobilized metal-ion affinity chromatography” 2000. Biotechnology and Bioengineering. vol. 67(1). pp. 104-111.
Martinez Torrecuadrada, J. L. et al. “Different architectures in the assembly of infectious bursal disease virus capsid expressed in insect cells”. 2000. Virology. vol. 278 (2). pp. 322-331.

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