ICOS mutants

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S387300

Reexamination Certificate

active

10072622

ABSTRACT:
Purified ICOS polypeptides are described, as well as nucleic acids encoding the polypeptides, vectors including the nucleic acids, host cells containing the vectors, and methods for using the polypeptides, nucleic acids, and host cells.

REFERENCES:
patent: 6521749 (2003-02-01), Ling et al.
patent: 6630575 (2003-10-01), Coyle et al.
patent: 2002/0156242 (2002-10-01), Tamatani et al.
Wang et al., J. Exp. Med., 2002, 8: 1033-1041.
Attwood, Science 2000; 290:471-473.
Skolnick et al., Trends in Biotech. 2000; 18(1):34-39.
Metzler et al., Nature Structural Biol. 1997; 4:527-531.
Bajorath et al., “Molecular modeling of CD28 and three-dimensional analysis of residue conservation in the CD28/CD152 family,”Journal of Molecular Graphics and Modelling, 1997, 15(2):135-139.
Bajorath, “A Molecular Model of Inducible Costimulator Protein and Three-Dimensional Analysis of its Relation to the CD28 Family of T Cell-Specific Costimulatory Receptors,”J. Mol. Model., 1999, 5:169-176.
Boise et al., “CD28 and apoptosis,”Curr. Opin. Immunol., 1995, 7:620-625.
Buonfiglio et al., “The T cell activation molecule H4 and the CD28-like molecule ICOS are identical,”Eur. J. Immunol., 2000, 30:3463-3467.
Chambers and Allison, “Co-stimulation in T cell responses,”Curr. Opin. Immunol., 1997, 9:396-404.
Dong et al., “B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion,”Nature Medicine, 1999, 5(12):1365-1369.
Hunkapiller and Hood, “Diversity of the Immunoglobulin Gene Superfamily,”Adv. Immunol., 1989, 44:1-63.
Hutloff et al., “ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28,”Nature, 1999, 397:263-266.
Krummel and Allison, “CTLA-4 Engagement Inhibits IL-2 Accumulation and Cell Cycle Progression upon Activation of Resting T Cells,”J. Exp. Med., 1996, 183:2533-2540.
Lenschow et al., “CD28/B7 System of T Cell Costimulation,”Annu. Rev. Immunol., 1996, 14:233-258.
Linsley and Ledbetter, “The Role of the CD28 Receptor During T Cell Responses to Antigen,”Annu. Rev. Immunol., 1993, 11:191-212.
Lucia et al., “Expression of the Novel T Cell Activation Molecule hpH4 in HIV-Infected Patients: Correlation with Disease Status,”Aids Research and Human Retroviruses, 2000, 16(6):549-557.
Metzler et al., “Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28,”Nature Structural Biology, 1997, 4(7):527-531.
Peach et al., “Complementarity Determining Region 1 (CDR1)- and CDR3-analogous Regions in CTLA-4 and CD28 Determine the Binding to B7-1,”J. Exp. Med., 1994, 180:2049-2058.
Rathmell and Thompson, “The Central Effectors of Cell Death in the Immune System,”Annu. Rev. Immunol., 1999, 17:781-828.
Walunas et al., “CTLA-4 Ligation Blocks CD28-dependent T Cell Activation,”J. Exp. Med., 1996, 183:2541-2550.
Wang et al., “Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS,”Blood, 2000, 96(8):2808-2813.
Yoshinaga et al., “T-cell co-stimulation through B7RP-1 and ICOS,”Nature, 1999, 402:827-832.
Yoshinaga et al., “Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS,”International Immunology, 2000, 12(10):1439-1447.

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