ICAM-related protein fragments

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

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530317, 530330, 530350, 530395, C07K 14705

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active

057706867

ABSTRACT:
DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R.

REFERENCES:
patent: 5081034 (1992-01-01), Bevilacqua et al.
patent: 5475091 (1995-12-01), Springes et al.
Hynes. Cell 69, 11-25, 1992.
Ashkenazi et al., "Protection Against Endotoxic Shock by a Tumor Necrosis Factor Receptor Immunoadhesin", Proc. Natl. Acad. Sci. USA, 88:10535-10539 (1991).
Ballatyne et al., "Assignment of the Gene for Intercellular Adhesion Molecule 1 (Icam-1) to Proximal Mouse Chromosome 9", Genomics, 9:547-550 (1991).
Beatty et al., "Definition of a Common Leukocyte Cell-Surface Antigen (Lp95-150) Associated with Diverse Cell-Mediated Immune Functions.sup.1 ", J. Immunol., 131:2913-2918 (1983).
Cannizzaro et al., "The Human Gene Encoding Phosphatidylinositol-3 Kinase Associated p85.alpha. Is at Chromosome Region 5q12-13.sup.1 ", Cancer Res., 51:3818-3820 (1991).
Capecchi, "Altering the Genome by Homologous Recombination", Science, 244:1288-1292 (1989).
Capon et al., "Designing CD4 Immunoadhesins for AIDS Therapy", Nature, 337:525-531 (1989).
Chen et al., "High Efficiency Transformation of Mammalian Cells by Plasmid DNA", Molecular and Cellular Biology, 7:2745-2752 (1987).
Corpet et al., "Multiple Sequence Alignment with Hierarchical Clustering", Nucleic Acids Res., 16(22):10881-10890 (1988).
de Fougerolles et al., "Characterization of ICAM-2 and Evidence for a Third Counter-Receptor for LFA-1", J. Exp. Med., 174:253-267 (1991).
de Fougerolles et al., "Intracellular Adhesion Molecule 3, a Third Adhesion Counter-Receptor for Lymphocyte Function Associated Molecule 1 on Resting Lymphocytes", J. Exp. Med., 175:185-190 (1992).
de Fougerolles et al., "Cloning and Expression of Intercellular Adhesion Molecule 3 Reveals Strong Homology to Other Immunoglobulin Family Counterreceptors for Lymphocyte Function-associated Antigen 1", J. Exp. Med., 177:1187-1192 (Apr. 1993).
Dustin et al., "Structure and Regulation of the Leukocyte Adhesion Receptor LFA-1 and Its Counterreceptors, ICAM-1 and ICAM-2", CSH Symp. Qual., 54:753-765 (1989).
Dustin et al., "T-Cell Receptor Cross-Linking Transiently Stimulated Adhesiveness Through LFA-1", Nature, 341:619-624 (1989).
Edwards, "Cell Adhesion Molecules as a Target for Therapy", Current Opinion in Therapeutic Patents, 1(11):1617-1630 (1991).
Fawcett et al., "Molecular Cloning of ICAM-3, a third Ligand for LFA-1, Constitutively Expressed on Resting Leukocytes", Nature, 360:481-484 (1992).
Geppert et al., "Association of Various T Cell-Surface Molecules With The Cytoskeleton", J. Immunol., 146(10):3298-3305 (1991).
Goding, "Conjugation of Antibodies with Fluorochromes: Modifications to the Standard Methods", J. Immunol. Meth., 13:215-226 (1976).
Hadam, "N11 Cluster Report: CDw50", pp. 667-670 in Knapp et al., eds., Leukocyte Typing IV, Oxford, Oxford University Press (1989).
Hochuli et al., "Genetic Approach to Facilitate Purification of Recombinant Proteins With A Novel Metal Chelate Adsorbent", Bio/Technology, 6:1321-1325 (1988).
Hunkapiller et al., "The Growing Immunoglobulin Gene Superfamily", Nature, 323:15-16 (1986).
Janknecht et al., "Rapid and Efficient Purification of Native Histidine-Tagged Protein Expressed by Recombinant Vaccinia Virus", Proc. Natl. Acad. Sci., USA, 88:8972-8976 (1991).
Johnstone et al., p. 52 in Blackwell, Immunochemistry in Practice, Oxford Press (1982).
Juan et al., "CDw50 and ICAM-3: Two Names for the Same Molecule", Eur. J. Immunol., 23:1508-1512 (1993).
Knapp et al., "CD Antigens 1989", Blood, 74(4):1488-1450 (Sep. 1989).
Kunkel et al., "Rapid and Efficient Site-Specific Mutagenesis Without Phenotypic Selection", Proc. Natl. Acad. Sci. USA, 82:488-492 (1985).
Kyte et al., "A Simple Method for Displaying the Hydropathic Character of a Protein", J. Mol. Biol., 157:105-132 (1982).
Ledbetter et al., "Antibodies to Tp67 and Tp44 Augment and Sustain Proliferative Responses to Activated T Cells", J. Immunol., 135(4):2331-2336 (1985).
Lozano et al., "Effect of Protein Kinase C Activators on the Phosphorylation and the Surface Expression of the CDw50 Leukocyte Antigen", Eur. J. Biochem., 203:321-326 (Mar. 1992).
Lozano et al., "Isolation and Characterization of a CDw50 Negative Jurkat T-Cell Line Variant", Leukemia Research, 17(1):9-16 (1993).
Newman et al., "PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily", Science, 247:1219-1222 (1990).
Pierschbacher and Ruoslahti, "Influence of Stereochemistry of the Sequence Arg-Gly-Asp-Xaa on Binding Specificity in Cell Adhesion", J. Biol. Chem., 262(36):17294-17298 (1987).
Simmons et al., "ICAM, An Adhesion Ligand of LFA-1, Is Homologous to the Neural Cell Adhesion Molecule NCAM", Nature, 331:624-627 (1988).
Springer, "Adhesion Receptors of the Immune System", Nature, 346:425-434 (1990).
Staunton et al., "The Arrangement of the Immunoglobulin-like Domains of ICAM-1 and the Binding Sites for LFA-1 and Rhinovirus", Cell, 61:243-254 (1990).
Vazeux et al., "Cloning and Characterization of a New Intercellular Adhesion Molecule ICAM-R", Nature, 360:485-488 (1992).
Vilella et al., "Involvement of the CDw50 Molecule in Allorecognition", Tissue Antigens, 36:203-210 (1990).
Williams et al., "The Immunoglobulin Superfamily--Domains For Cell Surface Recognition.sup.1,2 ", Ann. Rev. Immunol., 6:381-405 (1988).

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