Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-02-03
1998-12-01
Walsh, Stephen
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, 530324, 530325, 530326, 530300, 514 12, 514 13, A61K 3802, C07K 1400, C07K 704
Patent
active
058438858
ABSTRACT:
Short-chain peptides replicating fragments of functional domains derived from LFA-1 and ICAM-1 parent protein sequences serve to modulate the ICAM/LFA binding interaction. In one aspect of the invention, this modulation serves to block interprotein binding reactivity, as a peptide of the invention binds to a target protein in a manner that precludes the normal binding reaction between ICAM-1 and LFA-1. In another aspect of the invention, this modulation enhances the reactivity of a first peptide, as a second peptide induces a conformational change in the target protein from a first conformation to a second, more reactive, conformation. The peptides are used according to a method including the steps of providing the proteins and applying them to a population of cells.
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Benedict Stephen
Chan Marcia A.
Siahaan Teruna J.
Tibbetts Scott A.
Basi Nirmal S.
The University of Kansas
Walsh Stephen
LandOfFree
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