Iburprofen sustained release matrix and process

Details Iburprofen sustained release matrix and process Iburprofen sustained release matrix and process

1987-04-22

1989-02-21

Lusignan, Michael

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424472, 427 3, A61K 926

Patent

active

048063592

ABSTRACT:
An ibuprofen-sustained release tablet or tablet layer is formed by making a wet granulation using providone (PVP) in alcohol as the granulating fluid which is mixed with ibuprofen, ethylcellulose, a wicking agent e.g. microcrystalline cellulose, an erosion promoter e.g. pregelatinized starch, then drying and milling the granulation and blending with dry powdered erosion promotor, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the ibuprofen.

REFERENCES:
patent: 4264573 (1981-04-01), Powell et al.
patent: 4465660 (1984-08-01), David et al.
patent: 4684516 (1987-08-01), Bhutani
patent: 4753801 (1988-01-01), Oren et al.
Chowhan, Z. T. et al, Hardness Increase Induced by Partial Moisture Loss in Compressed Tablets and Its Effect on in vitro Dissolution, Feb. 1, 1978.

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