Ibuprofen resolution

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof


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562460, 562466, C07B 5700




A process for obtaining a substantially pure enantiomer of ibuprofen is described. The process utilizes first an enantiomerically enriched mixture of ibuprofen obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is dissolved in a solvent and solid racemic ibuprofen is separated, leaving a mother liquid comprising the solvent and the enriched enantiomer substantially free of the other enantiomer.

patent: 4417070 (1983-11-01), Arai et al.
patent: 4786731 (1988-11-01), Russell
patent: 4865770 (1989-09-01), Piselli
patent: 4983765 (1991-01-01), Lukas et al.
Jaques et al., Enantiomers, Racemates and Resolutions, pp. 193-196, John Wiley and Sons, Inc., New York (1981).
Sheldon, Chemistry & Industry, Apr. 2, 1990, pp. 212-219.


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