Ibuprofen-containing medicament

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514557, 514570, 514947, 514960, 514962, A61K 3119

Patent

active

055190570

ABSTRACT:
An ibuprofen-containing medicament which contains ibuprofen only in the (S)-(+)-form is disclosed. (S)-(+)ibuprofen is more than twice as active as the racemate which has until now been used in the treatment of rheumatism. This permits reduction of the quantity of active ingredient and the size of the tablets or dragees.

REFERENCES:
patent: 4555524 (1985-11-01), Gruber et al.
patent: 4690823 (1987-09-01), Lohner et al.
patent: 4877620 (1989-10-01), Loew et al.
The American College Dictionary--1970 p. 756.
Biochemical Pharmacology, vol. 35, No. 19 (Oct. 1985), pp. 3403-3405, Pergamon Journals Ltd., K. Williams et al., "The Steroselective Uptake of Ibuprofen Enantiomers into Adipose Tissue".
Current Medical Research and Opinion, vol. 3, No. 8 (1975), p. 552, S. S. Adams et al., "The Optical Isomers of Ibuprofen" month unavailable.
J. Pharm. Pharmacol., vol. 28 (1976), pp. 256-257, S. S. Adams et al., "Pharamacological Difference Between the Optical Isomers of Ibuprofen: Evidence for Metabolic Inversion of the (-)-Isomer" month unavailable.
Journal of Pharmaceutical Sciences, vol. 56 (1967), p. 1686, S. S. Adams et al., "Some Biological Properties of 2-(4-Isobutylphenyl)-Propionic Acid" month unavailable.
Biochemical and Biophysical Research Communications, vol. 61, No. 3 (1974), pp. 833-837, W. J. Wechter et al., "Enzymatic Inversion at Saturated Carbon: Nature and Mechanism of the Inversion of R(-)p-iso-Butyl Hydratropic Acid" month unavailable.
J. Pharm. Pharmacol., vol. 35 (1983), pp. 693-704, Andrew J. Hutt et al., "The Metabolic Chiral Inversion of 2-Arylpropionic Acids--A Noval Route with Pharmacological Consequences" month unavailable.
Clinical Pharmacokinetics, vol. 9 (1984), pp. 693-704, Andrew J. Hutt et al., "the Importance of Stereo-Chemistry in the Clinical Pharmacokinetics of the 2-arylproprionic Acid Non.varies.Steroidal Anti-Inflammatory Drugs" month unavailable.
The Journal of Pharmacology and Experimental Therapeutics, vol. 232, No. 3 (1985), pp. 636-643, J. W. Cox et al., "Ibuprofen Stereoisomer Hepatic Clearance and Distribution in Normal and Fatty in Situ Perfused Rat Liver" month unavailable.
American Society for Clinical Pharmacology & Therapeutics, vol. 42, No. 2 (Feb. 1987), p. 200, PIIL-7.
Clinical Pharmacology & Therapeutics, vol. 40, No. 1 (1986), pp. 1-7, Eugene M. Laska et al., "The Correlation Between Blood Levels of Ibuprofen and Clinical Analgesic Response" month unavailable.
Chemical Abstracts, vol. 106 (1987), Abstract No. 66922r (Daicel Chemical Industries, Ltd.) month unavailable.
Physicians' Desk Reference, 40th Edition, (1986), pp. 1854-1855, Edward R. Barnhart month unavailable.
Xenobiotica, vol. 3, No. 9 (1973), pp. 589-598, R. F. N. Mills et al., "The Metabolism of Ibuprofen" month unavailable.
Journal of Pharmaceutical Sciences, vol. 64, No. 5 (1975), pp. 798-801, Garrett J. Vangiessen et al., "GLC Determination of Ibuprofen [d1-2-(p-Isobutylphenyl)-Propionic Acid] Enantiomers in Biological Specimens" month unavailable.
Journal of Pharmaceutical Science, vol. 65, No. 2 (Feb. 1976), pp. 269-273, D. G. Kaiser et al., "Isomeric Inversion of Ibuprofen (R)-Enantiomer in Humans".
Anti-Inflammatory and Anti-Rheumatic Drugs, Eds. Rainsford and Path, CRC Press Inc., Boca Raton, Fla. (1985), p. 172, Anthony C. Allison et al., "Naproxen" month unavailable.
Angew, Chem. Internat. Edit., vol. 11, No. 6 (1972), pp. 460-472, T. Y. Shen, "Perspectives in Nonsteroidal Anti-Inflammatory Agents" month unavailable.
Nonsteroidal Anti-Inflammatory Agents, Chapter 62 in Burger's Medical Chemistry, 4th Edition, Part III, Wiley Interscience, New York (1981), pp. 1205-1271, T. Y. Shen month unavailable.
Br. J. Clin. Pharmac., vol. 19 (1985), pp. 669-674, E. J. D. Lee et al., "Stereoselective Disposition of Ibuprofen Enantiomers in Man" month unavailable.
The Journal of Pharmacology and Experimental Therapeutics, vol. 148. No. 3 (1965), pp. 373-379, Charles A. Winder et al., "Nociceptive Thresholds as Affected by Parenteral Administration of Irritants and Various Antinociceptive Drugs" month unavailable.
Proceedings of the Society of Experimental Biology and Medicine, vol. 118, (1965), pp. 763-766, H. Blumberg et al., "Use of Writhing Test for Evaluating Analgesic Activity of Narcotic Antagonists" month unavailable.
Journal of Pharmaceutical Sciences, vol. 73, No. 11 (Nov. 1984), pp. 1542-1544, E. J. D. Lee et al., American Pharmaceutical Association, "Liquid Chromatographic Determination and Plasma Concentration Profile of Optical Isomers of Ibuprofen in Humans".
Remington's Pharmaceutical Sciences, 15th Edition (1975), Mack Publishing Company, Easton, Pennsylvania 18042 Chapter 59, p. 1054, "John E. Humans" month unavailable.
Caldwell et al., "The Metabolic Chiral Inversion and Dispositional Enantioselectivity of the 2-Arylpropionic Acids and Their Biological Consequences", vol. 37, No. 1, pp. 106-114 (1988) month unavailable.
K. M. Williams and R. O. Day, AAS 17, Nonsteroidal Anti-Inflammatory Drugs-Basis for Variability in Response c. 1985 Berkhauser Verlag, Basel month unavailable.

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