IBDV VP2 epitope recognized by virus neutralizing and protective

Details IBDV VP2 epitope recognized by virus neutralizing and protective IBDV VP2 epitope recognized by virus neutralizing and protective

1993-04-26

1994-09-27

Kim, Kay K.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

4242041, 435 693, 435 697, 4352402, 4352523, 4353201, 536 234, 536 2372, 530350, 530403, A61K 3912, C12N 1509, C12N 121, C07K 1512

Patent

active

053505751

ABSTRACT:
A recombinant DNA molecule comprising a nucleotide sequence coding for a conformational epitope of the VP2 polypeptide of IBDV. In particular, a DNA molecule comprising a sequence which substantially corresponds to the AccI-SpeI fragment, and optionally the ScaI-XhoI fragment, of the IBDV genome segment coding for the VP2 polypeptide. Synthetic peptides or polypeptides, including fused polypeptides, prepared by expression of host cells containing these DNA molecules are also disclosed, as well as compositions for stimulating an immune response against IBDV comprising at least one such synthetic peptide or polypeptides.

REFERENCES:
Azad et al., (1985), Virology, 143:35-44.
Fahey et al., (1985), J. Gen. Virol., 66:2693-2702.
Fahey et al., (1985b), J. Gen. Virol., 66:1479-1488.
Hudson et al., (1986), Nucl. Acids. Res., 14(12):5001-12.

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