IAPs associated cell cycle proteins, compositions and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S069100, C435S041000, C435S252100

Reexamination Certificate



The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also, provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

patent: 6066474 (2000-05-01), Marcu
patent: WO 97/21809 (1997-06-01), None
patent: WO 98/44102 (1998-10-01), None
Salvesen et al (Nature Reviews Molecular Cell Biology, 2002, 3:401-410).
Hirashima (Int. Arch. Allergy Immunol., 2000, Suppl. 1:6-9).
Jiang et al (JBC, 2003, 278(7) 4763-4769).
Deveraux et al, (Genes & Dev., 1999, 13:239-252, p. 240, col. 2).
Schimmer et al, Hematology, 2005, 215-219, p. 216, col. 1, available at http://www.asheducationbook.org/cgi/content/full/2005/1/215).
Jin et al (J. Cell Science, 2001, 114 :4139-4140).
Alberts et al. (Molecular Biology of the Cell, 3rd edition, 1994, p. 465).
Shantz and Pegg (Int J of Biochem and Cell Biol., 1999, vol. 31, pp. 107-122).
McClean and Hill (Eur J of Cancer, 1993, vol. 29A, pp. 2243-2248).
Fu et al (EMBO Journal, 1996, vol. 15, pp. 4392-4401).
Ran et al. 18 (12): 1466. (2004).
Szak et al (Mo1. Cel. Biol., 21 :2001, 3375-3386).
Verma et al (Nature, 1997, vol. 389, pp. 239-242).
(Marshall (1995) Science, vol. 269, p. 1054, col. 3, paragraph 2, and p. 1055, col. 1), 269:1050-1055.
Eck et al (Gene-Based Therapy, In: The Pharmacological Basis of Therapeutics, Goodman and Gillman, Ed.s, 1996, pp. 77-101).
Ross et al. (Human Gene Therapy, 1996, vol. 7, pp. 1781-1790, see p. 1789, col. 1, first paragraph).
Orkin et al state (“Report and Recommendation of the Panel to Assess the NIH Investment in Research on Gene Therapy”, NIH, 1995).
Liston et al., Suppression of Apoptosis in Mammalian Cells by NAIP and a Related Family of IAP Genes, Nature, 1996, 379(6563): 349-53 (abstract only).
Avdonin, et al., “Apoptotic Proteins Reaper and Grim Induced Stable Inactivation in Voltage-Gated K+ Chammels,” Proc. Natl. Acad Sci\. USA, 95(20):11703-11708 (1998).
Bork, Genome Research, vol. 10, pp. 398-400 (2000).
Bowle et al., Science, vol. 247, pp. 1306-1310, (Mar. 1990).
Burgess, et al., The Journal of Cell Biology, vol. 111, pp. 2129-2138, (Nov. 1990).
Garkavstev, et al., “Suppression of the Novel Growth Inhibitor p33ING1 Promotes Neoplastic Transformation” Nat. Genet., 23(3):373 (Nov. 1999).
Garkavstev, et al., “Suppression of the Novel Growth Inhibitor p33ING1 Promotes Neoplastic Transformation” Nat. Genet., 14(4):415-420.
Garkavstev, et al., “The Candidate Tumour Suppressor p33ING1 Cooperates with p53 in Cell Growth Control” Nature, 391(6664):295-298 (1998).
Hay, et al., “Drosophila Homologs of Baculovirus Inhibitor of Apoptosis Proteins Function to Block Cell Death,” Cell, 83(7):1253-1262 (1995).
Helbing et al., “A Novel Candidate Tumor Suppressor, ING1, is involved in the Regulation of Apoptosis,” Cancer Res., 57(7):1255-1258 (1997).
Kaiser, et al., “Inhibition of reaper-induced Apoptosis by Interaction with Inhibitor of Apoptosis Proteins (IAPS),” Proc. Natl. Acad. Sci. USA 94(19):10183-10188 (1997).
Jager, et al., “Cancer-Testis Antigens and ING1 Tumor Suppressor Gene Product Are Breast Cancer Antigens: Characterization of Tissue-specific ING1 Transcripts and a Homologue Gene,” Cancer Res 59: 6197-6204 (Dec. 1999).
Jayawickreme et al., Current Opinion in Biotechnology, vol. 8, pp. 629-634, (1997).
Lazar, et al., Molecular and Cellular Biology, vol. 8, No. 3, pp. 1247-1252 (1988).
McCarthy, et al., “Apoptosis Induced by Drosophila Reaper and Grim in a Human System”, Attenuation by Inhibitor of Apoptosis Proteins (cIAPS), J. Biol. Chem., 273 (37): 24009-24015 (1998).
Shimada, et al., “Cloning of a Novel Gene (ING1L) Homologous to ING11, a Candidate Tumor Suppressor”, Cytogenet. Cell Genet., 83(3-4):232-235 (1998).
Vucic, et al., “Inhibitor of Apoptosis Proteins Physically Interact with and Block Apoptosis Induced by Drosophila Proteins HID and GRIM,” Mol. Cell. Biol. 18(6): 3300-3309 (1998).


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