I-4-amino-3-iodobenzylguanidine as imaging and therapeutic agent

Details I-4-amino-3-iodobenzylguanidine as imaging and therapeutic agent I-4-amino-3-iodobenzylguanidine as imaging and therapeutic agent

1984-04-27

1986-11-11

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 564237, G01N 4300, G01N 4900

Patent

active

046222170

ABSTRACT:
A novel compound, 4-amino-3-iodobenzylguanidine, in radioiodinated form is useful in radiopharmaceutical compositions in nuclear medicine as an imaging agent for the heart, adrenal medulla, and tumors of the adrenal medulla and can be used for treatment of tumors of the adrenal medulla. The radioactive compound can be readily made by reacting 4-aminobenzylguanidine and an N-chloro oxidant in the presence of a radioiodide.

REFERENCES:
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patent: 4083947 (1978-04-01), Monks et al.
patent: 4215045 (1980-07-01), Knapp, Jr.
"Adrenal Imaging Agents: Rationale, Synthesis, Formulation and, Metabolism", by W. H. Beierwaltes, et al, Seminars in Nuclear Medicin, vol. VIII, No. 1, Jan. 1978, p. 5.
"Imaging the Primate Adrenal Medullae with [.sup.123 I] and [.sup.131 I]Meta-Iodobenzylguanidine" by, Donald M. Wieland, Ph.D., Lawrence E. Brown, B.S., W. Leslie Rogers, Ph.D., David D. Marsh, Thomas J. Mangner, Ph.D., Dennis P. Swanson, M.S., W. H. Beierwaltes, M.D.
"Evolution of Pheochromocytoma in Multiple Endocrine Neoplasia: A Scintigraphic Portrayal Using .sup.131 I-Metaiodobenzylguanidine" by Timothy W. Valk, M.D., Marc S. Frager, M.D., Milton D. Gross, M.D., James C. Sisson, M.D., Donald M. Wieland, Ph.D., Dennis Swanson, M.S., William H. Beierwaltes, M.D.
"Scintigraphic Localization of Pheochromocytoma" by James C. Sisson, M.D., Marc S. Frager, M.D., Timothy W. Valk, M.D., Milton D. Gross, M.D., Dennis P. Swanson, M.S., Donald M. Wieland, Ph.D., Michael C. Tobes, Ph.D., William H. Beierwaltes, M.D., Norman W. Thompson, M.D.
"Myocardial Imaging in Man with .sup.123 I-Meta-Iodobenzylguanidine", by Robert C. Kline, M.D. Dennis P. Swanson, M.S., Donald M. Wieland, Ph.D., James H. Thrall, M.D., Milton D. Gross, M.D., Bertram Pitt, M.D., and William H. Beierwaltes, M.D.
Abstract entitled .sup.123 -I-m-Iodobenzylguanidine, A New Agent for Imaging the Human Myocardium",by R. C. Kline, D. P. Swanson, D. M. Wieland, J. H. Thrall, M. D. Gross, B. Pitt, W. H. Beierwaltes, "Circulation", vol. 62, Supp III, Oct. 1980.
Imaging the Primate Adrenal Medulla with [.sup.123 I] and [.sup.131 I] Meta-Iodobenzylguanidine: Concise Communication, by D. M. Wieland, L. E. Brown, M. C. Tobes, W. L. Rogers, D. D. Marsh, T. J. Mangner, D. P. Swanson, and W. H. Beierwaltes, "The Journal of Nuclear Medicine, vol. 22, No. 4, p. 358.
1981 Abstract Form for Scientific Papers and Scientific Exhibits of Society of Nuclear Medicine 28th Annual Meeting, entitled "A New Radioiodide Exchange Technique: The MW2 Method., by T. J. Mangner, J. L. Wu, D. M. Wieland and W. H. Beierwaltes.
Myocardial Imaging in Man with I-123 Meta-Iodobenzylguanidine by R. C. Kline, D. P. Swanson, D. M. Wieland, J. H. Thrall, M. D. Gross, B. Pitt, and W. H. Beierwaltes, "Journal of Nuclear Medicine," vol. 22, 1981, pp. 129-132.
Imaging the Adrenal Medulla with an I-131-Labeled Antiadrenergic Agent, by D. M. Wieland, D. P. Swanson, L. E. Brown, W. H. Beierwaltes, reprinted from the Journal of Nuclear Medicine, Feb., 1979, vol. 20, No. 2, pp. 155-158.
1981 Abstract Form for Scientific Papers and Scientific Exhibits for the Society of Nuclear Medicine 28th Annual Meeting, entitled "Localization of Pheochromocytomas with I-131-M-Iodobenzylguanidine (I-131-MIBG), by M. Gross, M. Frager, T. Valk, R. Kline, J. Sisson, D. Swanson, D. Wieland, N. Thompson, M. Tobes, W. Beierwaltes.
1981 Abstract Form for Scientific Papers & Scientific Exhibits for Society of Nuclear Medicine 28th Annual Meeting, entitled, "The Mechanism of m-IBG Localization: Drug Intervention Studies, by D. M. Wieland, L. E. Borwn, D. D. Marsh, T. J. Mangner W. H. Beierwaltes with 4 pages of supporting data.
Wieland et al, T. Med. Chem. 27(1984) 149-155.

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