Hypridoma and monoclonal antibody which inhibits blood coagulati

Details Hypridoma and monoclonal antibody which inhibits blood coagulati Hypridoma and monoclonal antibody which inhibits blood coagulati

1991-09-13

1996-04-09

Parr, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

5303871, 5303881, 53038825, C12N 512, C07K 1600, C07K 1618

Patent

active

055061346

ABSTRACT:
Coagulation protein antagonists are disclosed, which include monoclonal-type antibodies and related cell lines disclosed for the production of specific, neutralizing antibodies against factors VII and VIIa and the tissue factor/factor VIIa bimolecular complex, which antibodies are useful for the prevention or treatment of thrombotic and related diseases, for immunoaffinity isolation and purification of factors VII and VIIa and the tissue factor/factor VIIa complex, and for determination of factors VII or VIIa and the tissue factor/factors VII or VIIa complex in a biological sample.

REFERENCES:
patent: 4382083 (1983-05-01), Thomas
Carson et al., Blood, 70:490-493, Aug. 1987.
Takase, et al., J. Clin Pathol, 41:337-341, 1988.
Warr et al., 75 Blood 1481, 1990.
Carson et al., 66 Blood 152, 1985.
Drake et al., 134 American Journal of Pathology 1807, 1989.
Drake et al., 109 Journal of Cell Biology 389, 1989.
"Preliminary Characterization of a Panel of Monoclonal Antibodies to Human Factor VII", Coppola et al., Curr. Stud. Hematol. Blood Transfus. (1991) 58:187-193.
"Monoclonal Antibody (VII-M31) to Bovine Factor VII: A Specific Epitope in the .gamma.-Carboxyglutamic Acid Domain"; Higashi et al., J. Biochemistry (1990) 108:654-662.
Waldman, Science 252:1657-1662 (1991).

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