Hypoxia-mediated neurogenesis assay

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

Reexamination Certificate

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C435S325000, C435S367000, C435S375000, C435S004000, C436S063000

Reexamination Certificate

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06924142

ABSTRACT:
Methods are described for the production of neurons or neuronal progenitor cells. Multipotent neural stem cells are proliferated in the presence of growth factors and erythropoietin which induces the generation of neuronal progenitor cells. The erythropoietin may be exogenously applied to the multipotent neural stem cells, or alternatively, the cells can be subjected to hypoxic insult which induces the cells to express erythropoietin.

REFERENCES:
patent: 5750376 (1998-05-01), Weiss et al.
patent: 6165783 (2000-12-01), Weiss et al.
patent: 6368854 (2002-04-01), Weiss et al.
patent: WO 93/01275 (1993-01-01), None
patent: WO 94/10292 (1994-05-01), None
patent: WO 95/03821 (1995-02-01), None
patent: WO 95/13364 (1995-05-01), None
patent: WO 96/15226 (1996-05-01), None
Bauer, C., “Upregulation of erythropoietin by hypoxia in the brain of mammals”, Weiner Klinische Wochenschrift 109:535 (1997).
Bayer, Shirley A., “Neuron Production in the Hippocampus and Olfactory Bulb of the Adult Rat Brain: Addition or Replacement?”, Annals N.Y. Acad. Sci., 457:163-173 (1985).
Digicaylioglu, M. et al., “Localization of specific erythropoietin binding sites in defined areas of the mouse brain”, Proc. Nat'l Acad. Sci. 92:3717-3720 (1995).
Freed, Curt R., et al., “Survival of Implanted Fetal Dopamine Cells and Neurologic Improvement 12 to 46 Months After Transplantation for Parkinson's Disease”, N. Eng. J. Med., 327(22):1549-1555 (1992).
Juul, S.E. et al., “Erythropoietin and erythropoiein receptor in the developing human central nervous system”, Pediatric Research 43:40-49 (1998).
Juul, S.E. and R.D. Christensen, “Erythropoietin (EPO) may promote neuronal survival following hypoxia, by repressing apoptosis”, Pediatric Research 41:291A (1997).
Kaplan, Michael S., “Neurogenesis in the 3-Month-Old Rat Visual Cortex”, J. Comp. Neuro., 195:323-338 (1981).
Marti, H.H. et al., “Detection of erythropoietin in human liquor: intrinsic erythropoietin production in the brain”, Kidney Int'l 51:416-418 (1997).
Perlow, Mark J., et al., “Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System”, Sci., 204:643-647 (May 1979).
Potten, C.S., et al., “Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the Crypt”, Dev., 110:1001-1020 (1990).
Rakic, Pasko, “Limits of Neurogenesis in Primates”, Sci., 227:1054-1056 (Mar. 1985).
Reynolds, Brent A., et al., “Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System”, Sci., 255:1707-1710 (Mar. 1992).
Sorokan, S.T. and S. Weiss, “Erythropoietin mediates increased neurogenesis by embryonic CNS stem cells following a modes hypoxic insult”, Society For Neurosciences Abstracts 23:320 (1997).
Sorokan, T. and S. Weiss, “Effects of hypoxia on neuronal production from embryonic murine CNS stem cells”, Mol. Bio. of the Cell 7 (supp): 371A (1996).
Spencer, Dennis D., et al., “Unilateral Transplantation of Human Fetal Mesencephalic Tissue Into the Caudate Nucleus of Patients with Parkinson's Disease”, N. Eng. J. Med., 327(22):1541-1548 (Nov. 1992).
Weiss, S. et al., “Is there a neural stem cell in the mammalian forebrain?”, Trends In Neurosciences 19:387-393 (1996).
Widner, Hakan, et al., “Bilateral Fetal Mesencephalic Grafting in Two Patients with Parkinsonism Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)”, N. Eng. J. Med., 327(22):1556-1563 (Nov. 1992).
Masuda et al. (1994).J. Biol. Chem. 269: 19488-19493.
Masuda et al. (1997).Brain Res. 746: 63-70.
Bauer et al. (1995).J. Perinat. Med. 23: 7-12.

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