Hypoxia inducible VEGF plasmid for ischemic disease

Details Hypoxia inducible VEGF plasmid for ischemic disease Hypoxia inducible VEGF plasmid for ischemic disease

2004-02-23

2009-12-29

Whiteman, Brian (Department: 1635)

Chemistry: molecular biology and microbiology

Vector, per se

Reexamination Certificate

active

07638322

ABSTRACT:
Plasmids useful for treating ischemic disease, such as ischemic heart disease, are described. The plasmids express vascular endothelial growth factor (VEGF) under the control of a promoter (RTP801) that is up-regulated under hypoxic conditions. Pharmaceutical compositions for treating ischemic disease include mixtures of the hypoxia-regulated VEGF plasmids and pharmaceutically acceptable carriers. Methods for treating ischemic disease include administering such pharmaceutical compositions to a person in need of such treatment.

REFERENCES:
patent: 6548633 (2003-04-01), Edwards et al.
patent: 2003/0104973 (2003-06-01), Einat et al.
Su Hua et al: “Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model”; Proceedings of the National Academy of Sciences of USA, National Academy of Science, Washington, DC, US, vol. 99, No. 14, Jul. 9, 2002, pp. 9480-9485.
Jeffrey M. Isner, Myocardial Gene Therapy, 415 Nature 234-239 (2002).
Minhyung Lee, et. al., SP-1 Dependent Regulation of the RTP801 Promotor and Its Application to Hypoxia-Inducible VEGF Plasmid for Ischemic Disease, 21 Pharaceutical Research, 736-741 (2004).
Tzipora Shoshani, et. al., Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, RTP801, Involved in Apoptosis, 22 Molecular and Cellular Biology 2282-2293 (2002).
Seppo Yiä-Herttuala, et. al., Cardiovascular Gene Therapy, 355 The Lancet 213-222 (2000).

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