Hypoxia inducible factors and uses thereof for inducing...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Details

C536S024300, C536S024330, C536S024500, C435S006120, C435S091100, C435S325000, C435S375000

Reexamination Certificate

active

07608698

ABSTRACT:
This invention provides HIF-3α nucleic acid and sequences. Also provided are methods for using HIF-3α nucleic acids, proteins, fragments, antibodies, probes, and cells, to characterize HIF-3α, modulate HIF-3α cellular levels, induce angiogenesis, improve muscular function, and treat coronary and cardiac diseases in mammals.

REFERENCES:
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patent: WO 9928464 (1999-06-01), None
patent: WO 9928464 (1999-06-01), None
patent: WO 0009657 (2000-02-01), None
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Hara, Shuntaro et al. “Expression and Characterixation of Hypoxia-Inducible Factor (HIF)-3α in Human Kidney: Suppression of HIF-Mediated Gene Expression by HIF-3α”Biochemical and Biophysical Research Communications287:808-813 (2001).
International Search Report corresponding to PCT/CA02/00752 mailed Dec. 11, 2002.
Lamerdin, Je, et al. “Putative Homolog of Hypoxia Inducible Factor Three Alpha”Database SWALLDatabase accession No. Q9Y2N7. Online. Abstract only. (Nov. 12, 1999).
Strausberg, Robert. “Homo sapienscDNA Clone IMAGE:2960025”Database EMBLDatabase accession No. BE250712. Online. Abstract only. (Jul. 14, 2000).
Gu YZ et al., “Molecular Characterization and Chromosomal Localization of a Third Alpha-Class Hypoxia Inducible Factor Subunit, HIF3ALPHA”, Gene Expr 1998; 7(3): 205-13.
Kietzmann T. et al., “Perivenous Expression of the mRNA of the Three Hypoxia-Inducible Factor Alpha-Subunits, HIF1ALPHA, HIF2ALPHA and HIF3ALPHA, in Rat Liver”, Biochem J Mar. 15, 2001;354 (Pt 3): 531-7.
Hara S. et al., “Expression and Characterization of Hypoxia-Inducible Factor (HIF)-3ALPHA in Human Kidney: Suppression of HIF-Mediated Gene Expression by HIF-3ALPHA”, Biochem Biophys Res Commun Oct. 5, 2001;287(4): 808-13.
One page corresponding to GENBANK™, accession No. AF079154 (Jan. 1, 1999).
One page corresponding to GENBANK™, accession No. AAC99397 (Jan. 1, 1999).
Two pages corresponding to GENBANK™, accession No. AB054067 (Jan. 18, 2002).

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