Hypoxia-inducible factor 1alpha variants and methods of use

Details Hypoxia-inducible factor 1alpha variants and methods of use Hypoxia-inducible factor 1alpha variants and methods of use

2007-03-20

2007-03-20

Carlson, Karen Cochrane (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

10831380

ABSTRACT:
This invention relates to unique variant forms of HIF-1 alpha polypeptide that are stable under hypoxic and nonhypoxic conditions and their use in the treatment of disorders involving oxygen homeostasis.

REFERENCES:
patent: 2002/0048794 (2002-04-01), Poellinger et al.
patent: 2003/0045686 (2003-03-01), Kaelin et al.
Huang et al., “Leu-574 of HIF-1-alpha is Essential for the von Hippel-Lindau (VHL)-mediated Degradation Pathway”, The Journal of Biological Chemistry. Nov. 1, 2002. vol. 277, No. 44, pp. 41750-41755.
Masson et al., “Independent Function of Two Destruction Domains of Hypoxia-Inducible Factor-alpha Chains Activated by Prolyl Hydroxylation”. The EMBO Journal. 2001. vol. 20, No. 18, pp. 5197-5206.
Huang et al. Regulation of Hypoxia-Inducible Factor 1-alpha is Mediated by an Oxygen-dependent Degradation Domain Via the Ubiquitin-Proteasome Pathway. Proceedings of the National Academies of Science. Jul. 1998. Vo. 95, pp. 7987-7992.

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