Hypothermic preservation of mammalian hearts by blocking the Na.

Details Hypothermic preservation of mammalian hearts by blocking the Na. Hypothermic preservation of mammalian hearts by blocking the Na.

1994-09-22

1996-03-12

Knode, Marian C.

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

Including perfusion; composition therefor

514409, 514461, 514518, A01N 102, A01N 4338, A01N 4308, A01N 4102

Patent

active

054985196

ABSTRACT:
A method for preserving mammalian hearts while under ischemic conditions is accomplished by exposing the heart to a preservation solution containing a pharmacologically effective concentration of a Na.sup.+ /K.sup.+ /Cl.sup.- co-transporter blocker agent, such as Furosemide, Bumetanide or Piretanide, thereby extending survival of the heart.

REFERENCES:
Askenasy N et al., "Sodium ion transport in rat hearts during cold ischemic storage", Magn. Reson. Med., 1992, 28:249-263.
Pike MM et al., ".sup.23 Na NMR measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion", Am. J. Physiol, 1990, 259:H1767-H1773.
Geck, P et al., "The Na-K-2Cl Cotransport system", J. Membrane Biol., 1986, 91:97-105.
Pike MM et al., ".sup.23 Na and .sup.39 K nuclear magnetic resonance studies of perfused rat hearts", Biophys. J., 1985, 48:159-173.
Ledingham S et al., "The St. Thomas' Hospital cardioplegic solution", J. Thorac. Cardiovasc. Surg., 1987, 93:240-246.
Christlieb Iy et al, J Thoraac Cardin Vase Surg. 84:689-95 (1982).
Borchgrevink PC et al, Pharmacology and Toxicology 64:100-106 (1989).

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