Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-04-22
2008-04-22
Mondesi, Robert (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S300000, C424S185100
Reexamination Certificate
active
11096661
ABSTRACT:
There are provided a method for selection of a substance which is capable of controlling activation of prorenin where an adjusting ability of the activation of prorenin by protein-protein interaction in a profragment region of prorenin as indicator is used; a prorenin activation controlling substance having a function of controlling the activation of prorenin based on protein-protein interaction by a profragment region of prorenin; and hypotensor, organ hypertrophy suppressor and arterial thickening suppressor containing the prorenin activation controlling substance as an effective ingredient.
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patent: 10-279600 (2000-07-01), None
Suzuki, F. et al., Biosci. Biotechnol. Biochem. 63(3): 550-554 Mar. 1999, “Non-proteolytic activation of human prorenin by anti-prorenin prosegment (pf#1: 1P-15P) Antiserum”.
International Search Report dated Jul. 3, 2001.
Dubin et al., “Synthetic Peptide Inhibitors of Prorenin Activation,”Symposium of rennin inhibitors: Present and future held at the 12thscientific meeting of the International Society of Hypertension, Osaka, Japan, May 28, 1988, J. Hypertens., vol. 7, suppl.2, pp. S71-S74 (1989).
Suzuki, F. et al.,Journal of Biological Chemistry, vol. 278, No. 25, pp. 22217-22222 (2003).
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Cohen et al., “New monoclonal antibodies directed against the propart segment of human prorenin as a tool for the exploration of prorenin conformation,” Journal of Immunological Methods, No. 184, 1995 (pp. 91-100).
Ishida Yuichi
Murakami Kazuo
Suzuki Fumiaki
Desai Anand
Kilyk & Bowersox P.L.L.C.
Mondesi Robert
Protein Express Co., Ltd.
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