Hypotensors

Details Hypotensors Hypotensors

2005-05-31

2005-05-31

Weber, Jon (Department: 1653)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C514S012200, C424S094660, C530S387100

Reexamination Certificate

active

06900020

ABSTRACT:
There are provided a method for selection of a substance which is capable of controlling activation of prorenin where an adjusting ability of the activation of prorenin by protein-protein interaction in a profragment region of prorenin as indicator is used; a prorenin activation controlling substance having a function of controlling the activation of prorenin based on protein-protein interaction by a profragment region of prorenin; and hypotensor, organ hypertrophy suppressor and arterial thickening suppressor containing the prorenin activation controlling substance as an effective ingredient.

REFERENCES:
patent: 5945512 (1999-08-01), Murakami et al.
patent: 10-279600 (2000-07-01), None
Suzuki, F. et al. Journal of Biological Chemsitry vol. 278, No. 25, pp. 22217-22222 (2003).*
International Search Report dated Jul. 3, 2001.
Dubin et al., “Synthetic Peptide Inhibitors of Prorenin Activation,” Symposium of rennin inhibitors: Present and future held at the 12thscientific meeting of the International Society of Hypertension, Osaka, Japan, May 28, 1988, J. Hypertens., vol. 7, suppl.2, pp. S71-S74 (1989).

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