Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-04-22
2008-04-22
Mondesi, Robert (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S300000, C424S185100
Reexamination Certificate
active
07361637
ABSTRACT:
There are provided a method for selection of a substance which is capable of controlling activation of prorenin where an adjusting ability of the activation of prorenin by protein-protein interaction in a profragment region of prorenin as indicator is used; a prorenin activation controlling substance having a function of controlling the activation of prorenin based on protein-protein interaction by a profragment region of prorenin; and hypotensor, organ hypertrophy suppressor and arterial thickening suppressor containing the prorenin activation controlling substance as an effective ingredient.
REFERENCES:
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patent: 10-279600 (2000-07-01), None
Suzuki, F. et al., Biosci. Biotechnol. Biochem. 63(3): 550-554 Mar. 1999, “Non-proteolytic activation of human prorenin by anti-prorenin prosegment (pf#1: 1P-15P) Antiserum”.
International Search Report dated Jul. 3, 2001.
Dubin et al., “Synthetic Peptide Inhibitors of Prorenin Activation,”Symposium of rennin inhibitors: Present and future held at the 12thscientific meeting of the International Society of Hypertension, Osaka, Japan, May 28, 1988, J. Hypertens., vol. 7, suppl.2, pp. S71-S74 (1989).
Suzuki, F. et al.,Journal of Biological Chemistry, vol. 278, No. 25, pp. 22217-22222 (2003).
Office Action issued by Canadian Patent Office dated Jul. 4, 2006 in counterpart Canadian Patent Application No. 2,404,644.
Cohen et al., “New monoclonal antibodies directed against the propart segment of human prorenin as a tool for the exploration of prorenin conformation,” Journal of Immunological Methods, No. 184, 1995 (pp. 91-100).
Ishida Yuichi
Murakami Kazuo
Suzuki Fumiaki
Desai Anand
Kilyk & Bowersox P.L.L.C.
Mondesi Robert
Protein Express Co., Ltd.
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