Hypotensive active peptides

Details Hypotensive active peptides Hypotensive active peptides

1984-07-27

1986-04-29

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 2601125R, A61K 3743, C07K 508, C07K 506, C07K 510

Patent

active

045857571

ABSTRACT:
The present invention provides a hypotensive composition comprising a peptide having the structure X-Y, Y-X, or a salt thereof, wherein X is proline or proline-proline and Y is arginine, lysine, arginine-arginine, lysine-lysine, arginine-lysine, or lysine-arginine, together with a pharmaceutically suitable diluent.

REFERENCES:
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patent: 4146611 (1979-03-01), Ondetti
patent: 4225579 (1980-09-01), Kleinberg
patent: 4237046 (1980-12-01), Bodanszky
patent: 4284624 (1981-08-01), Natarajan
patent: 4428938 (1984-07-01), Kisfaludy
Pang, et al., "Hypotensive Action of Parathyroid Hormone Preparations on Rats and Dogs," Proc. Natl. Acad. Sci., U.S.A., 77:675-678 (1980).
Tenner, et al., "Pharmacological Comparison of bPTH-(1-34) and Other Hypotensive Peptides in the Dog", Peptides, 1:285-288, (1980).
Pang, et al., "Hypotensive Action of Synthetic Fragments of Parathyroid Hormone," J. Parmacol. Exp. Ther., 216:567-571, (1981).
Pang, et al., "The Vasorelaxant Action of Parathyroid Hormone Fragments on Isolated Rat Tail Artery", (submitted for publication to the journal Blood Vessel, not yet published).
Chem. Abstr., vol. 99, (1983) 116320c.
Chem. Abstr., vol. 101, (1984) 144331k.
Chem. Abstr., vol. 97 (1982) 66850m.
Biochem. and Biophys. Res. Commun., vol. 100, No. 1 (1981) 31-36.

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