Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Plant proteins – e.g. – derived from legumes – algae or...
Patent
1990-08-29
1991-12-17
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Plant proteins, e.g., derived from legumes, algae or...
530370, 530406, 530410, 530411, 530359, 424 91, A61K 3936
Patent
active
050736280
ABSTRACT:
A novel hyposensitization agent was prepared by covalently attaching a saccharide to a cedar pollen allergen having a partial amino acid sequence of Ala-Ile-Asn-Ile-Phe-Asn- beginning at its N-terminal. The hyposensitization agent, when compared with an intact cedar pollen allergen, extremely accelerates the production of immunoglobulin G and M antibodies which are specific to intact cedar pollen allergen, but extremely reduces the production of immunoglobulin E antibody which is specific to the allergen. Thus, the hyposensitization agent is administrable to cedar pollinosis patients with no anaphylaxis and allergy, and cuts hyposensitization period to about 1/3 to 1/200.
REFERENCES:
patent: 4939239 (1990-07-01), Matsuhashi et al.
Chem. Abstracts, vol. 112, 1990, 62606s, effective date Mar. 22, 1989, Hayashibara.
Ando Shunsaku
Matsuhashi Tyoku
Mitsuhashi Masakazu
Usui Mitsuko
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
Schain Howard E.
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