Hypolipidemic agents

Details Hypolipidemic agents Hypolipidemic agents

1973-04-02

1976-12-28

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424285, 2602472B, 260268H, 26029367, 260295R, 2602955R, 260309, 26032636, 2603473, 2603475, C07D30754

Patent

active

040001644

ABSTRACT:
Substituted furoylacetic acids and esters, and pharmaceutically acceptable salts thereof of the following general structure are useful as hypolipidemic agents: ##STR1## wherein Y represents oxygen or divalent sulfur; R represents a straight or branched alkyl chain containing from 10 to 20 carbon atoms and may be saturated or may be unsaturated containing from 1 to 4 double bonds; R.sup.1 represents hydrogen, or an ester group.

REFERENCES:
patent: 2834789 (1958-05-01), Clauson-Kaas
M. Stiles "J. of Am. Chem. Soc." vol. 81, 1959 pp. 2598-2599.
Fieser et al. "Reagents for Organic Synthesis" vol. 1 pp. 631-633.
Burger, Medicinal Chemistry, part II, 3rd Ed., pp. 1123-1163 (1970).
Dunlop et al., The Furans, frontispage and pp. 601 to 608, (NY) Reinhold Pub. Corp. (1953).
Chemical Abstracts, vol. 82, abstracts No. 16694h and 16695j (1975).

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