Hypohidrotic ectodermal dysplasia genes and proteins

Details Hypohidrotic ectodermal dysplasia genes and proteins Hypohidrotic ectodermal dysplasia genes and proteins

2006-10-03

2006-10-03

Nguyen, Dave Trong (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S390500, C530S350000, C800S008000

Reexamination Certificate

active

07115555

ABSTRACT:
The DNA and amino acid sequences are disclosed for a ligand (EDA1-II) and receptor (dl in mice and DL in humans) involved in ectodermal dysplasia. Also disclosed are variant DNA and amino acid sequences, and therapeutic applications of the ligands and receptors.

REFERENCES:
patent: 5556786 (1996-09-01), Kere et al.
patent: 5700926 (1997-12-01), Kere et al.
patent: 6159462 (2000-12-01), Matthews et al.
Medline, Medical encylcopedia: Ectodermal dysplasia assessed May 12, 2004 at the nlm.nih.gov.
Gaide and Schneider, Permanent correction of an inherited ectodermal dysplasia with recombinant EDA, Nature Medicine vol. (5), May 2003, pp. 614-618.
Meng R.D. and El-Deiry, W.S. Tumor Suppressor Genes as Targets for Cancer Gene Therapy. 1999. Gene Therapy of Cancer,Chapter 1. pp. 3-18.
Torchilin V.P. and Lukyanov A.N. Peptide and protein drug delviery to and itno tumors; challenges and solutions. DDT, Mar. 2003, vol. 8(6): p. 259-266.
Drögemüller et al, X-linked anhidrotic ectodermal dysplasia (ED1) in men, mice, and cattle, Genet. Sel. Evol. 35 (Suppl. 1) (2003) S137-145.
Smahi et al, The NF-KB signalling pathway in human disease, Human Molecular Genetics, 2002, vol. 11,No. 20, pp. 2371-2375.
Headon & Overbeek, Involvement of a novel Tnf receptor homologue in hair follicle induction, Nature Genetics, vol. 22, 1999, pp. 370-374.
Durmowicz,The EDA gene is atarget of, but does not regualte Wnt signaling, GENE, 2002, vol. 285, pp. 203-211.
Ezer, S. et al.: “Anhidrotic ectodermal dysplasia (EDA) protein expressed in MCF-7 cells associates with cell membrane and induces rounding” Hum. Molec. Genetics, 1997, 6:1581-1587.
Ferguson, B. et al.: “Cloning ofTabby,the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain” Hum. Molec. Genetics, 1997, 6:1589-1594.
GenBank Accession No. AF004435.
Headon, D. et al.: “Involvement of a novel Tnf receptor homologue in hair follicle induction” Nature Genetics, 1999, 22:370-374.
Kere, J. et al.: “X-Linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein” Nature Genetics, 1996, 13:409-416.
Kumar, A. et al.: “Ectodermal dysplasia receptor activates the nuclear factor kappa B, c-Jun N-terminal kinase and cell death pathways and binds to ectodysplasmin A” J. Biol. Chem, 2000.
GenBank Accession No. U59227.
Majumder, K. et al.: “YAC rescue of downless locus mutations in mice” Mammalian Genome, 1998, 9:863-868.
Monreal, A. et al.: “Identification of a New Splice Form of theEDA1Gene Permits Detection of Nearly All X-Linked Hypohidrotic Ectodermal Dysplasia Mutations” Am. J. Hum. Genet., 1998, 63:380-389.
Pakula, et al.: “Genetic Analysis of Protein Stability and Function,” Annu. Rev. Genet., 1989, 23:289-310.
Srivastava, A. et al.: “The Tabby phenotype is caused by mutation in a mouse homologue of theEDAgene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains” Proc. Natl. Acad. Sci. USA, 1997, 94:13069-13074.
GenBank Accession No. AF016628.
Yan, M. et al.: “Two-Amino Acid Molecular Switch in an Epithelial Morphogen That Regulates Binding to Two Distinct Receptors” Science, 2000, 290:523-527.

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