Hypogylcemic oxaluric acid derivatives

Details Hypogylcemic oxaluric acid derivatives Hypogylcemic oxaluric acid derivatives

1986-02-07

1987-11-24

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514235, 514255, 514315, 514423, 514529, 514530, 514531, 514551, 514563, 544169, 544390, 546245, 548538, 548966, 560118, 560121, 560123, 560124, 560125, 560169, 562500, 562503, 562505, 562506, 562507, 562560, A61K 31535, C07D29520

Patent

active

047089547

ABSTRACT:
Pharmaceutical compositions containing an oxaluric acid derivative of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is hydrogen; an alkyl group or a cycloalkyl group; or R.sub.1 and R.sub.2 are joined to form a heterocyclic ring with the nitrogen atom to which they are both attached; and R.sub.3 is hydrogen or an alkyl group. These compounds have excellent hypoglycemic effects with low toxcicity and safety.

REFERENCES:
Chemical Abstracts, 66:75960j, (1967), [S. Moshchitskii et al., 2H. Org. Khim., 2(12), 2164-7, (1966)].
Chemical Abstracts, 57:14218f, (1962), [C. Shepherd, Australian J. Biol. Sci., 15, 483, (1962)].
Chemical Abstracts, 50:3225c, (1956), [J. Andrews et al., Arch. Biochem. and Biophys. 56, 405, (1956)].
Chemical Abstracts, 57:9846c, (1962), [N. Poddubnaya et al., 2H. Oshch. Khim. 31, 3820, (1961)].
Chemical Abstracts, 25:1830, (1930), [T. Johnson et al., J. Am. Chem. Soc., 53, 1082, (1931)].
Chemical Abstracts, 19:2933, (1925), [K. Slotta, J. Prakt. Chem., 110, 264, (1925)].
Chemical Abstracts, 18:531, (1924), [M. Biltz et al., J. Prakt. Chem., 106, 108, (1923)].

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