Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1975-05-20
1976-04-13
Moyer, Donald B.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
424195, A61K 3170, A61K 3578
Patent
active
039505189
ABSTRACT:
A compound prepared from the extract of Xanthium strumarium (cockleburr) characterized by being a white crystalline glycoside having a decomposition point of 278.degree.-279.degree.C.; a molecular formula of C.sub.31 H.sub.48 O.sub.24 S.sub.2, the aglycone portion of the molecule having a molecular formula of C.sub.19 H.sub.28 O.sub.4 ; substantially no ultraviolet absorption above 200 m.mu.; infrared spectrum showing hydrogen bonded OH absorption, 3440 cm.sup.-.sup.1 ; C--H stretch, 2940 cm.sup.-.sup.1 ; carbonyl stretch, 1735 cm.sup.-.sup.1 ; C--O stretch, 1250 cm.sup.-.sup.1 ; and other absorptions at 1640; 1460; 1380; 1040; 1000; 900; and 800 cm.sup.-.sup.1 ; a nuclear magnetic resonance spectrum in deuterium oxide showing a broad absorption at 304, 230, 162, 134, 92 and 58 cps relative to external tetramethylsilane standard; and the mass spectrum of the silylated derivative gives a mass fragment of 952 amu. Hypoglycemic compositions consisting essentially of the foregoing described compound prepared from cockleburrs in admixture with a non-toxic, pharmaceutically-acceptable carrier. A method of reducing blood sugar levels in animals comprising administering a therapeutically effective concentration of the inventive compound in a pharmaceutically suitable carrier intravenously, orally, intraperitoneally and intramuscularly. The method of preparing a hypoglycemic pharmacologically active therapeutic compound from cockleburrs (Xanthium strumarium).
REFERENCES:
chemical Abstracts Vol. 31: 6734.sub.9 ; Vol. 37: 6343.sub.8 and Vol. 40: 6759.sub.2.
Craig, Jr. John C.
Turner Carlton E.
Moyer Donald B.
The University of Mississippi
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