Hypoglycemic and growth-promoting polypeptides isolated from bac

Details Hypoglycemic and growth-promoting polypeptides isolated from bac Hypoglycemic and growth-promoting polypeptides isolated from bac

1990-07-23

1991-12-03

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 21, 514866, 530303, 530304, A61K 3702, A61K 3726, C07C10352

Patent

active

050700740

ABSTRACT:
This application discloses an invention comprising a polypeptide fraction isolated from commercial bacitracin and which contains most if not all of the anti-insulinase activity of bacitracin while exhibiting few if any of the antibacterial properties. The invention herein described also involves the use of this polypeptide fraction given orally or if given parenterally either together (as composite) or in sequence as a means of treating diabetics. For such purposes, the insulin and anti-insulinase polypeptide fraction may be used as separate substances or chemically linked by a wide variety of chemical linking agents well known in the art. In addition to clinical uses, the application describes a method of using the polypeptide fraction as a growth promoter substance to be added to animal feed and also a composition useful for this purpose.

REFERENCES:
Diabetes Dialogue, Am. J. Med., 79 (Suppl 2B), 1-44 (1985).
Duckworth et al., Endocrinology, 108, 1142-1147 (1981).
Roth et al., Biochem. Biophys. Res. Commun., 98, 431-438 (1981).
Peavy et al., Diabetes, 34, 217-221 (1985).
Duckworth et al., Proc. Nat. Acad. Sci., 69, 3698-3702 (1972).
Patrick et al., Antibiotics and Chemotherapy, 1, 133-137 (1951).
Kennedy et al., Clinica Chem. Acta, 70, 1-31 (1976).
Method Enzymology 112, Pt. A (1985), Ch. 16, 17, 19, 20, 21, 23.
Tsuji et al., J. Chromatog., 99, 597-608 (1974).

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