Hypoglycemic agent from cryptolepis

Details Hypoglycemic agent from cryptolepis Hypoglycemic agent from cryptolepis

1994-09-28

1999-06-29

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 61, 546 62, C07D20980

Patent

active

059170522

ABSTRACT:
The use of extracts from Cryptolepis sp. or quindoline alkaloids such quindoline and cryptolepine contained therein as hypoglycemic agents, as well as methods for obtaining the hypoglycemic agents are described. According to a preferred embodiment, the extracts are derived from Cryptolepis sanguinolenta. As hypoglycemic agents, the extracts or quindoline alkaloids such as quindoline or cryptolepine are useful for treating insulin-dependent (type I) and non-insulin-dependent (type II) diabetes.

REFERENCES:
patent: 3374264 (1968-03-01), Uskokovic et al.
patent: 4826850 (1989-05-01), Yamato
Paulo et al., 1994, "In vitro antibacterial screening of Cryptolepis sanguinolenta alkaloids", J Ethnopharmacol 44:127-130.
Oyekan and Ablordeppey, 1993, "The mechanism(s) of the antiaggregatory effects of cryptolepine: The role of cyclic adenosine monophosphate and celluar Ca.sup.2+ ", Gen Pharmacol 24(2):461-469.
Proceedings from the 1st International seminar on cryptolepine, University of Science and Technology Kumasi, Jul. 27-30, 1983, Boakye-Yiadom & Bamgbose (eds.), pp. 1-82.
Spitzer et al., 1991, "Total Assignment of the proton and carbon NMR spectra of the alkaloid quindoline -- Utilization of HMQC-TOCSY to indirectly establish protonated carbon-protonated carbon connectivities", J Heterocyclic Chem 28:2065-2070.
Wilson et al., 1922 "Polynuclear Heterocyclic aromatic types. Part I. Some indenoquinoline derivatives", J Chem Soc pp. 827-839.
Fichter and Rohner, 1910, "Uber einige derivate des chindolins", Chem. Ber. 43:3489-3499.
Fichter and Probst, 1907, "Zur kenntnis des methyl-chindolanols", Chem. Ber. 40:3478.
Okeyam, 1994, Role of the Endothelium and Cyclic GMP in Renal Vasodilator Responses to Cryptolepine in Rats, J. Cardiovasc. Pharmacol. 23:602-611.
Oyekan and Ablordeppey, 1993, Effects of Cryptolepine on Collagen-Induced Aggregation and on the Mobilization and Metabolism of Arachidonic Acid by Rabbit, Gen. Pharmac. 24:1285-1290.
Rauwald et al., 1992, Cryptolepis sanguinolenta:Antimuscarinic Properties of Cryptolepine and the Alkaloid Fraction at M1,M2 and M3 Receptors, Planta Medica, 58:486-488.
Cimanga et al., 1991, Biological Activities of Cryptolepine, An Alkaloid from Cryptolepis sanguinolenta, Planta Medica 57 Supp. 2 A98-A99.
Tackie et al., 1991, Assignment of the Proton and Carbon NMR Spectra of the Indoloquinoline Alkaloid Cryptolepine, J. Heterocycl. Chem. 28:1429-1435.
Ablordeppy et al., 1990, .sup.1 H-NMR and .sup.13 C-NMR Assigments of Cryptolepine A 3 : 4-Benz-.delta.-carboline Derivative Isolated from Cryptolepis sanguinolenta,Planta Medica 56:416.
Oyekan and Okafor, 1989, Effects of Cryptolepine Alone and in Combination with Dipyridamole on a Mouse Model of Arterial Thrombosis, J. Ethnopharmacology 27:141-148.
Potential Antimalarial in Ghanian Plant, IMS Pharmaceutical Marketletter, May 7, 1984, p. 13.
Cryptolepine Hydrochloride, Drugs Future, 1982, 7(7):466.
Bamgbose and Noamesi, 1981, Studies on Cryptolepine, Planta Medica 41:392-396.
Noamesi et al., 1980, The Alpha-Adrenoceptor Blocking Properties of Cryptolepine on the Rat Isolated Vas Deferens, Planta Medica 39:51-56.
Gunatilaka et al., 1980, Studies on Medicinal Plants of Sri Lanka, Planta Medica, 39:66-72.
Boakye-Yiadom et al., 1979, Cryptolepine Hydrochloride Effect on Staphylococcus aureus, J. Pharm. Sci. 68:1510.-1514.
Dwuma-Badu et al., 1978, Constituents of West African Medicinal Plants XX: Quindoline from Cryptolepis sanguinolenta, J. Pharm. Sci. 67:433-434.
Gellert et al., 1951, Die Konstitution des Alkaloids Cryptolepin, Helv. Chim. Acta 34:642-651.
Raymond-Hamet et al., 1938, Pharmacolgie -- Sur les Effects Hypotenseurs et Vaso-dilatateurs de la Cryptolepine, C.R. Acad. Sci. 207:1015-1018.
Raymond-Hamet et al., 1937, Sur Quelques Proprietes Physiologuques des Alcaloides du Crytloepis sanguinolenta Schlechter, C.R. Soc. Biol. 126:768-770.
Cliniquart et al., 1929, Sur la compesition chimique de "Cryptolepis triangularis" plante congolaise, Bull. Acad. R. Med. Belg. 12:627-635.
Fichter and Boehringer, 1906, Ueber Chindolin, Chemische Berichte 39:3932-3942.
Baldwin and Magnus (eds.), 1994, in Organic Syntheses Based on Name Reactions and Unnamed Reactions, vol. 11, p. 36.
Blount et al., 1929, "Stereoisomerism in polycyclic systems. Part VI", J Chem Soc pp. 1975-1987. derivatives", Heterocycles 33(1):147-152.
Degutis and Ezyarskaite, 1986, "Alkylation of quindoline and quindoline-11-carboxylic acid", Khimiya Geterotsiklicheskikh Soedinenii 10:1375-1379.
Desarbre and Merour, 1994, "Synthesis and reactivity of 35(13):1995-1998.
Ezyarskaite, 1989, "On the synthesis of 7-bromoquindoline derivatives", Izv Khim 22:101-105.
Galun et al., 1979, "Derivatives of indole-3-oxyacetic acid", J Heterocyclic Chem 16:641-643.
Giraud, 1879, "Sur quelques derives de l'indigotine", Comptes Rendus pp. 104-105.
Giraud, 1880, "Preparation de l'indoline et de ses composes", Comptes Rendus pp. 1429-1430. chinoline, S,S-dioxide und thionierungsprodukte", Arch Pharm 314:76-84.
Gorlitzer and Weber, 1982, "Hemmung der thrombocytenaggregation durch anellierte chinoline mit 3-dimethylaminopropylmercapto-substituenten", Arch Phar 315:532-537. (`Dioxychindolin`)", Arch Pharm 314:850-852.
Gorlitzer and Weber, 1980, "Anellierte chinoline III), 313:27-34.
Gorlitzer et al., 1994, "Anti-malaria active amodiaquine and cycloquine type", Pharmazie 49:231-235.
Gorlitzer, 1976, "Untersuchungen an 1,3-dicarbonylverbindungen, 6. Mitt. Anerllierte chinolone", Arch Pharm 309:18-25. 314:852-861.
Gorlitzer et al., 1995, "Gegen malaria wirksame
Gorlitzer, 1979, "Anellierte chinolone II, N- and O-alkylierungsprodukte", Arch Pharm 312:254-261.
Holt and Petrow, 1948, "Carbazoles, carbolines, and related compounds. Part III. Quinindoline derivatives", pp. 922-924.
Holt and Petrow, 1947, "Carbazoles, carbolines, and related compounds. Part I. Quindoline derivatives", pp. 607-611.
Holt and Petrow, 1948, "Carbazoles, carbolines, and related compounds. Part II. Transformations of some quarternary salts of quindoline", pp. 919-922.
Jezerskaite et al., 1989, "New heterocyclic sensitizers for electrophotography", Izv Khim 22:113-121.
Kempter et al., 1963, Z Chem 3:352-353.
Merour et al., 1982, "Syntheses of 2(5)-substituted 1-acetyl-3-oxo-2,3-dihydroindoles, 3-acetoxy-1-acetylindoles, and of 2-methyl-5-methoxyindole-3-acetic acid", Synthesis 12:1053-1056.
Mooradian et al., 1949, "A new series of testosterone esters", J Amer Chem Soc 71:3372-3374.
Nenitzescu and Raileanu, 1958, "Synthesen des heteroauxins, des tryptamins und des serotonins", Chem Ber 91:1141-1145.
Ossman et al., 1988, "Synthesis of 2-cyanomethyl-3, 1-benzoxazin-4(H)-one", Egypt J Chem 31(3):381-385.
Schoen and Bogdanowicz-Szwed, 1964, "The reaction of .alpha.-indanone anils with phenylisocyanate. Anilides of 1-arylamino-indene-2-carboxylic acids", Roczniki Chemii Ann Soc Chim Polonorum 38:425-435.
Schulte et al., 1972, "Kondensierte indole aus 2-chlorindoaldehyd-(3)", Arch Pharmaz 305:523-533.
Schutzenberger, 1877, "Note sur un nouveau derive de l'indigotine", Comptes Rendus pp. 147-149.
Sevodin et al., 1982, "New methods for the synthesis of quindolines on the basis of 1,5-diketones of the indolinone series", Chem Heterocyclic Compounds 18(8):865.
Sevodin et al., 1984, "New method of synthesis of quindolines from 1,5-diketones of the indoline series", Chem Heterocyclic Comp 20(12):1374-1380. and derivatives", J Heterocyclic Chem 15:1379-1382.
Takeuchi et al., 1991, "Synthesis and antitumor activity of 39(6):1629-1631.
Takeuchi et al., 1992, "Synthesis and antitumor activity of fused quinoline Pharm Bull 40(6):1481-1485.
Yamato et al., 1989, "Synthesis and antitumor activity of fused tetracyclic quinoline derivatives", J Med Chem 32:1295-1300.
Yamato et al., 1992, "Synthesis and antitumor activity of fused quinoline Pharm Bull 40(2):528-530.
Yamato et al., 1990, "Synthesis and antitumor activity of fused quinoline derivatives", Chem Pharm Bull 38(11):3048-3052.

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