Hypoglycemic agent

Details Hypoglycemic agent Hypoglycemic agent

1993-11-23

1995-03-14

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514529, 514530, 549304, 549467, 546169, 546323, 560 40, 560 41, 562445, 562450, A61K 31215, C07C10172

Patent

active

RE0348783

ABSTRACT:
A compound of D-phenylalanine derivative for hypoglycemic use, represented by the general formula ##STR1## R.sup.1 is selected from hydrogen, alkyl of 1 to 5 carbon atoms, aryl of 6 to 12 carbon atoms, aralkyl of 6 to 12 carbon atoms, ##STR2## --CH.sub.2 CO.sub.2 R.sup.3, --CH(CH.sub.3)--OCO--R.sup.3, and --CH.sub.2 --OCO--C(CH.sub.3).sub.3 ; R.sup.2 is selected from groups comprising aryl of 6 to 12 carbon atoms, a hetero six-membered ring, a hetero five-membered ring, cycloalkyl, or cycloalkenyl, any of which groups may have one or more substituents; and R.sup.3 is selected from hydrogen and alkyl of 1 to 5 carbon atoms; the salts thereof, and precursors which can be converted thereto in the human or animal body.
Some of the compounds are novel per se.

REFERENCES:
patent: 4650785 (1987-03-01), Toyoshima et al.
patent: 4670584 (1987-06-01), Toyoshima et al.
Toyoshima et al., "Preparation of D-Phenylalanine Derivatives and Their Use as Hypoglycemic Agents", CA 106 85057d (1987).
European Search Report/Application No. 86 30 2217/26-11-1987.

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