Hypoglycaemic peptides and methods of use thereof

Details Hypoglycaemic peptides and methods of use thereof Hypoglycaemic peptides and methods of use thereof

2007-02-06

2007-02-06

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S018700, C530S326000, C530S330000

Reexamination Certificate

active

10481662

ABSTRACT:
A peptide of the formula (Xaa)n1-Xaa1-His-Thr-Asp-(Xaa)n2, wherein Xaa is any amino acid; Xaa1is a hydrophobic amino acid, preferably Gly or Val; n1 is 0–10; and n2 is 0–10; and use thereof in regulating in vivo blood glucose levels in a human or other mammal, particularly in the treatment of Type 2 diabetes in a human. Preferably, the peptide is a tetrapeptide selected from Gly-His-Thr-Asp and Val-His-Thr-Asp. These hypoglycaemic peptides are isolated from human urine and they also have been chemically synthesized.

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patent: WO 98/09170 (1998-03-01), None
Ng et al. Insulin Potentiating Action of a Peptide Fraction from Human Urine. Diabetes. Dec. 1974, vol. 23, No. 12, pp. 950-956.
Boge, A., et al., “A Nonradioactive Assay for the Insulin Receptor Tyrosine Kinase: Use in Monitoring Receptor Kinase Activity After Activation of Overexpressed Protein Kinase C Alpha and High Glucose Treatment,”Anal. Biochem. 231(2):323-32, Nov. 1, 1995.

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