Hypocholesterolemic hydrogenation products and process of prepar

Details Hypocholesterolemic hydrogenation products and process of prepar Hypocholesterolemic hydrogenation products and process of prepar

1980-12-01

1982-09-28

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Synthetic or structurally-modified peptidoglycan or...

A61K 31335, A61K 31215, C07C 6974, C07C 5911

Patent

active

043518443

ABSTRACT:
Hydrogenation of the natural fermentation product, mevinolin, MK-803, results in the production of dihydro- and tetra-hydro derivatives and hydrogenation of the naturally occurring dihydromevinolin results in the formation of a tetrahydro derivative. These several products with the exception of cis-(4.alpha..beta., 8.alpha..beta.-)-tetrahydromevinolin are potent inhibitors of cholesterol biosynthesis.

REFERENCES:
patent: 3072709 (1963-01-01), Saucy et al.
patent: 3344169 (1967-09-01), Los
patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4282155 (1981-08-01), Smith et al.
patent: 4293446 (1981-10-01), Willard
patent: 4294846 (1981-10-01), Albers-Schonberg et al.
patent: 4319039 (1982-03-01), Albers-Schonberg et al.
patent: 4323648 (1982-04-01), Tanzawa et al.

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