Hypocholesteremic fermentation products and process of preparati

Details Hypocholesteremic fermentation products and process of preparati Hypocholesteremic fermentation products and process of preparati

1979-06-15

1980-11-04

Milestone, Norma S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560256, 435125, C07D30930

Patent

active

042319382

ABSTRACT:
Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.

REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4049495 (1977-09-01), Endo et al.
patent: 4137322 (1979-01-01), Endo et al.
A. Endo et al., Eur. J. Biochem., vol. 77 (1977), pp. 31-36.
A. Endo et al., The Journal of Antibiotics, vol. XXIX, No. 12 (1976), pp. 1346-1348.
A. Endo et al., FEBS Letters, vol. 72, No. 2 (1976), pp. 323-326.
A. G. Brown et al., J.C.S. Perkin I (1976), pp. 1165-1169.

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