Hypertonic isochloremic formulations for treatment of hypovolemi

Details Hypertonic isochloremic formulations for treatment of hypovolemi Hypertonic isochloremic formulations for treatment of hypovolemi

1993-09-24

1995-08-22

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

424646, 424680, 424682, 514 2, 514 23, 514 59, 514 60, 514557, A61K 3332, A61K 3326, A61K 3314, A61K 3306

Patent

active

054438489

ABSTRACT:
The present invention relates to hypertonic crystalloid resuscitation fluids particularly useful in treating hemorrhagic shock. A pharmaceutical formulation prepared and selected ratios of sodium chloride and sodium acetate with a total osmolar concentration exceeding 500 mOsm can be used as a small volume resuscitation fluid which has little effect on plasma chloride levels. Arterial pressure is improved to the point of sustaining oxygen supply to tissues and organs with a significant increase in oxygen delivery and consumption.

REFERENCES:
patent: 3993750 (1976-11-01), Fox, Jr.
patent: 4049795 (1977-09-01), Laborit
patent: 4908350 (1990-03-01), Kramer et al.
patent: 4927806 (1990-05-01), Kramer et al.
patent: 5248507 (1993-09-01), e Silva et al.
Excerpt from Advanced Trauma Life Support Instructor Manual, 1989.
Article by Kramer et al., "Small--volume Resuscitation With Hypertonic Saline Dextran Solution," Surgery, vol. 100, No. 2, pp. 239-246, Aug. 1986.
Abstract 21745 by Jan Modig, "Advantages of dextran 70 over Ringer acetate solution in shock treatment and in prevention of adult respiratory distress syndrome: A randomized study in man after traumatic-hemorrhagic shock," Resuscitation 10(4):219-226, 1983.
Article by John B. Cone et al., "Beneficial Effects of a Hypertonic Solution for Resuscitation in the Presence of Acute Hemorrhage," The Am. J. of Surgery, vol. 154, pp. 585-588, Dec. 1987.
Article by M. Rocha e Silva et al., "Hyperosmotic sodium salts reverse severe hemorrhagic shock: other solutes do not," The Am. Physiological Society, pp. H751-H762, 1987.
Abstract #122 by I. T. Velasco et al., "A Comparison of Hyperosmotic and Hyperoncotic Resuscitation from Severe Hemorrhagic Shock in Dogs," Circulatory Shock, vol. 21, No. 4, p. 338, 1987.
Ekblad, H. et al., "Water, Sodium and Acid--Base Balance in Premature Infants: Therapeutical Aspects," Acta P diatrica Scandinavica, 76(1):47-53, 1987.
Smith, G. J. et al., "A Comparison of Several Hypertonic Solutions for Resuscitation of Bled Sheep," Journal of Surgical Research, 39(6):517-528, 1985.
International Search Report, mailed Sep. 4, 1992.

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