Hypersensitive acid-labile handle for solid-phase peptide synthe

Details Hypersensitive acid-labile handle for solid-phase peptide synthe Hypersensitive acid-labile handle for solid-phase peptide synthe

1990-08-31

1993-03-23

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 62, 558242, 564164, 564165, 548378, C07C 6976

Patent

active

051965666

ABSTRACT:
Novel acid-labile tris(alkoxy)benzyl ester handles for use in linking protected amino acid or peptides to a support during peptide synthesis are disclosed. Methods for producing the handles, for linking them to solid support resins and for using the resin-linked handles in peptide synthesis are disclosed.

REFERENCES:
Florsheimer, A. and B. Riniker, Proceedings of the European Peptide Symposium Abstract 95, (Sep. 1990).
Albericio, F. and G. Barany, Tetrahedron Letters 32:1015-1018 (1991).
Durr H. et al., Proceedings of the European Peptide Symposium Abstract 96, (Sep. 1990).
Albericio, F. et al., J. Organ. Chem. 55:3730-3743 (1990).
Barany et al., Int. J. Peptide Protein Res. 30:703-739 (1987).
Sheppard and Williams, J. Chem. Soc. Chem. Commun. 587-589 (1982).
Mergler et al., Tetrahedron Letter 29:4009-4012 (1988).
Albericio et al., Forum Peptides (1984).
Albericio and Barany, Int. J. Peptide Protein Res. 30:206-216 (1987).

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