Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Alkali or alkaline earth chloride
Patent
1990-06-15
1994-03-08
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Alkali or alkaline earth chloride
514 2, 514 23, 514561, 514921, A61K 3314, A61K 3700, A61K 3170, A61K 31195
Patent
active
052925358
ABSTRACT:
The invention provides a physiologically acceptable solution for treating circulatory shock in mammals which is hyperosmotic as compared to blood plasma. The solution contains a reabsorbable solute and sodium salt in a concentration having an osmolarity in excess of about 1000 mOsms. The physiologically acceptable solution can be easily administered by rapid infusion of 4-6 ml/kg body weight and results in rapid normalization of circulatory function.
REFERENCES:
patent: 3356570 (1967-12-01), Butcher, Jr.
patent: 4025650 (1977-05-01), Gans et al.
patent: 4042687 (1977-08-01), Gans et al.
patent: 4042688 (1977-08-01), Gans et al.
patent: 4049795 (1977-09-01), Laborit
patent: 4053589 (1977-10-01), Gans et al.
patent: 4308255 (1981-12-01), Raj et al.
patent: 4434160 (1984-02-01), Jeretin et al.
patent: 4446154 (1984-05-01), Osterholm
patent: 4446155 (1984-05-01), Osterholm
patent: 4604286 (1986-08-01), Kawajiri
patent: 4670261 (1987-06-01), Samejima et al.
patent: 4908350 (1990-05-01), Kramer et al.
patent: 4981687 (1991-01-01), Fregly et al.
Modig, Biol. Abstracts, 78(3) 2473 No. 21745 (1983).
Pristoupil and Stanislav, Chem. Abstracts, vol. 82, No. 4772b (1985).
Shimazaki et al., Body Fluid Changes During Hypertonic Lactated Saline Solution Therapy for Burn Shock, J. Trauma 17:38-43 (1977).
Lopes et al., Hyperosmotic NaCl and severe hemorrhagic shock: role of the innervated lung, Am. J. Physiol. 241:H883-H8889.
Rush, B. F., Treatment of experimental shock: Comparison of the effects or norepinephrine, Dibenzyline, dextran, whole blood and balanced saline solutions, Surgery, 61:938-944 (1967).
Velasco et al., Hyperosmotic NaCl and severe hemorrhagic shock, Am. J. Physiol., 239:H664-H673 (1980).
Fraser and Cowell, Nature and Treatment of Wound Shock and Allied Conditions, Journal A.M.A., pp. 521-535, Feb. 23 (1918).
Danowski et al., The treatment of Shock Due to Salt Depletion; Comparison of the Hemodynamic Effects of Isotonic Saline, of Hypertonic Saline, and of Isotonic Glucose Solutions, J.C.I., 25:130-138 (1946).
Brooks et al., Osmolar and Electrolyte Changes in Haemorrhagic Shock The Lancet, pp. 521-527, Mar. 9, 1963.
Silbert, S., The Treatment of Thromboangiitis Obliterans, Journal A.M.A., pp. 1759-1761, Jun. 5, 1926.
Baue et al, A Comparison of Isotonic and Hypertoni Solutions on Blood on Blood Flow and Oxygen Consumption in the Initial Treatment of Hemorrhagic Shock, J. Trauma 1:743-756 (1967).
Gunther Robert A.
Kramer George C.
Sheikh Azad
Henley III Raymond J.
Regents of the University of California
Waddell Frederick E.
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