Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1998-03-18
2000-09-26
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
424520, 424562, 424568, 424 91, A61K 4900, G01N 3100, G01N 3348
Patent
active
061239186
ABSTRACT:
Compounds and samples may be screened for estrogenic, androgenic, and thyroid hormone activity simultaneously, by administering the compound or sample to larval amphibians or tissue obtained therefrom, particularly Hyperolius argus, prior to the end of metamorphosis, and observing developmental differences between the test amphibians and normal development for said amphibians.
REFERENCES:
Hayes, T.B., 1997, "Hormonal Mechanisms as Potential Constraints on Evolution: Examples form the Anura," Amer. Zoo. 37:482-490.
Richards, C.M., 1982, "The Alteration of Chromatophore Expression by Sex Hormones in the Kenyan Reed Frog, Hyperolius viridiflavus," Gen. Comp. Endocrin. 46:59-67.
Blair, A.P., 1946, "Effects of Various Hormones on Primary and Secondary Sex Characters of Juvenile Bufo fowleri," J. Exp. Zool. 103:365-400.
Greenberg, B., 1942, Some Effects of Testosterone on the Sexual Pigmentation and Other Sex Characters of the Cricket Frog (Acris gryllus), J. Exp. Zool. 91:435-451.
Dees Jos,e G.
Jones Dameron
The Regents of the University of California
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